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Silicon particles as trojan horses for potential cancer therapy

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dc.contributor.author Fenollosa Esteve, Roberto es_ES
dc.contributor.author Garcia-Rico, Eduardo es_ES
dc.contributor.author Alvarez, Susana es_ES
dc.contributor.author Alvarez, Rosana es_ES
dc.contributor.author Yu, Xiang es_ES
dc.contributor.author Rodriguez, Isabel es_ES
dc.contributor.author Carregal-Romero, Susana es_ES
dc.contributor.author Villanueva, Carlos es_ES
dc.contributor.author Garcia-Algar, Manuel es_ES
dc.contributor.author Rivera-Gil, Pilar es_ES
dc.contributor.author de Lera, Angel R. es_ES
dc.contributor.author Parak, Wolfgang J. es_ES
dc.contributor.author Meseguer Rico, Francisco Javier es_ES
dc.contributor.author Alvarez-Puebla, Ramon A. es_ES
dc.date.accessioned 2017-01-18T12:39:07Z
dc.date.available 2017-01-18T12:39:07Z
dc.date.issued 2014-09-16
dc.identifier.issn 1477-3155
dc.identifier.uri http://hdl.handle.net/10251/77010
dc.description.abstract [EN] Background: Porous silicon particles (PSiPs) have been used extensively as drug delivery systems, loaded with chemical species for disease treatment. It is well known from silicon producers that silicon is characterized by a low reduction potential, which in the case of PSiPs promotes explosive oxidation reactions with energy yields exceeding that of trinitrotoluene (TNT). The functionalization of the silica layer with sugars prevents its solubilization, while further functionalization with an appropriate antibody enables increased bioaccumulation inside selected cells. Results: We present here an immunotherapy approach for potential cancer treatment. Our platform comprises the use of engineered silicon particles conjugated with a selective antibody. The conceptual advantage of our system is that after reaction, the particles are degraded into soluble and excretable biocomponents. Conclusions: In our study, we demonstrate in particular, specific targeting and destruction of cancer cells in vitro. The fact that the LD50 value of PSiPs-HER-2 for tumor cells was 15-fold lower than the LD50 value for control cells demonstrates very high in vitro specificity. This is the first important step on a long road towards the design and development of novel chemotherapeutic agents against cancer in general, and breast cancer in particular. es_ES
dc.description.sponsorship The authors acknowledge financial support from the following projects FIS2009-07812, MAT2012-35040, PROMETEO/2010/043, CTQ2011-23167, CrossSERS, FP7 MC-IEF 329131, and HSFP (project RGP0052/2012) and Medcom Tech SA. Xiang Yu acknowledges support by the Chinese government (CSC, Nr. 2010691036). en_EN
dc.language Inglés es_ES
dc.publisher BioMed Central es_ES
dc.relation.ispartof Journal of Nanobiotechnology es_ES
dc.rights Reconocimiento (by) es_ES
dc.title Silicon particles as trojan horses for potential cancer therapy es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1186/s12951-014-0035-7
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/329131/EU/SERS ultrasensitive universal sensing of proteins through cross-reactive sensor arrays/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/HFSP//RGP0052%2F2012/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/CSC//2010691036/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//FIS2009-07812/ES/Coloides De Silicio. Sintesis, Caracterizacion Y Aplicaciones Tecnologicas./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2012-35040/ES/APLICACIONES BASADAS EN COLOIDES DE SILICIO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2010%2F043/ES/TRANSMISIÓN Y LOCALIZACIÓN DE ONDAS EN METAMATERIALES/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//CTQ2011-23167/ES/DETECCION UNIVERSAL ULTRASENSIBLE DE PROTEINAS MEDIANTE SISTEMAS DE SENSORES DE REACTIVIDAD CRUZADA Y SERS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Tecnologías Físicas: Acústica, Materiales y Astrofísica - Centre de Tecnologies Físiques: Acústica, Materials i Astrofísica es_ES
dc.description.bibliographicCitation Fenollosa Esteve, R.; Garcia-Rico, E.; Alvarez, S.; Alvarez, R.; Yu, X.; Rodriguez, I.; Carregal-Romero, S.... (2014). Silicon particles as trojan horses for potential cancer therapy. Journal of Nanobiotechnology. 12:1-10. https://doi.org/10.1186/s12951-014-0035-7 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1186/s12951-014-0035-7 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 10 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.relation.senia 286894 es_ES
dc.identifier.pmid 25223512 en_EN
dc.identifier.pmcid PMC4428529 en_EN
dc.contributor.funder European Commission
dc.contributor.funder Medcom Tech SA es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación
dc.contributor.funder Ministerio de Economía y Competitividad
dc.contributor.funder Generalitat Valenciana
dc.contributor.funder Human Frontier Science Program Organization es_ES
dc.contributor.funder China Scholarship Council es_ES
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