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dc.contributor.author | Guerzoni, Samuele | es_ES |
dc.contributor.author | Deplaine, Harmony | es_ES |
dc.contributor.author | El Haskouri, Jamal | es_ES |
dc.contributor.author | Amoros, Pedro | es_ES |
dc.contributor.author | Monleón Pradas, Manuel | es_ES |
dc.contributor.author | Edlund, Ulrica | es_ES |
dc.contributor.author | Gallego Ferrer, Gloria | es_ES |
dc.date.accessioned | 2017-02-03T09:56:30Z | |
dc.date.available | 2017-02-03T09:56:30Z | |
dc.date.issued | 2014-01 | |
dc.identifier.issn | 0883-9115 | |
dc.identifier.uri | http://hdl.handle.net/10251/77567 | |
dc.description.abstract | Composite scaffolds of poly(l-lactide acid) and hydroxyapatite are of great interest in bone tissue engineering, but their mechanical properties are typically inferior to scaffolds of pure poly(l-lactide acid) due to agglomeration of the particles and weak interfacial component interaction. Fabrication strategies like double sonication of hydroxyapatite or increasing the amount of this inorganic filler do not effectively enhance the mechanical performance. In this study, poly(l-lactide acid) composites combining two types of fillers, mesoporous silica (SiO2) nanoparticles and hydroxyapatite, were developed to reinforce the poly(l-lactide acid) scaffold without any loss of bioactivity. A 5% addition of SiO2 nanoparticles to hydroxyapatite nanopowder and subjecting the scaffold formulation to double sonication increased the Young's modulus from 5 MPa (pure poly(l-lactide acid) scaffold) to almost 7 MPa (poly(l-lactide acid)/hydroxyapatite/SiO2 scaffold). In addition, the composite was able to deposit a layer of biomimetic hydroxyapatite both on the surface and interior of the scaffold after 21 days of immersion in a simulated body fluid. The manufacturing method was straightforward and economically viable and does not require any chemical modification of the particles' surfaces. | es_ES |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Science and Innovation through the DPI2010-20399-C04-03 project. CIBER-BBN was an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010 and Consolider Program. CIBER Actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | SAGE Publications | es_ES |
dc.relation.ispartof | Journal of Bioactive and Compatible Polymers | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Poly(l-lactide acid) | es_ES |
dc.subject | silica composite scaffolds | es_ES |
dc.subject | hydroxyapatite | es_ES |
dc.subject | mechanical properties | es_ES |
dc.subject | bioactivity | es_ES |
dc.subject | bone tissue engineering | es_ES |
dc.subject.classification | MAQUINAS Y MOTORES TERMICOS | es_ES |
dc.title | Combination of silica nanoparticles with hydroxyapatite reinforces PLLA scaffolds without loss of bioactivity | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1177/0883911513513093 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//DPI2010-20399-C04-03/ES/DISEÑO Y FABRICACION DE UNA PLATAFORMA BIOMIMETICA TIPO SCAFFOLD%2FSOPORTE PARA LA REGENERACION DEL CARTILAGO ARTICULAR/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada | es_ES |
dc.description.bibliographicCitation | Guerzoni, S.; Deplaine, H.; El Haskouri, J.; Amoros, P.; Monleón Pradas, M.; Edlund, U.; Gallego Ferrer, G. (2014). Combination of silica nanoparticles with hydroxyapatite reinforces PLLA scaffolds without loss of bioactivity. Journal of Bioactive and Compatible Polymers. 29(1):15-31. https://doi.org/10.1177/0883911513513093 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi. org/10.1177/0883911513513093 | es_ES |
dc.description.upvformatpinicio | 15 | es_ES |
dc.description.upvformatpfin | 31 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 29 | es_ES |
dc.description.issue | 1 | es_ES |
dc.relation.senia | 285317 | es_ES |
dc.identifier.eissn | 1530-8030 | |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |