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Long-term and transgenerational effects of cryopreservation on rabbit embryos

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Long-term and transgenerational effects of cryopreservation on rabbit embryos

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dc.contributor.author Lavara García, Raquel es_ES
dc.contributor.author Baselga Izquierdo, Manuel es_ES
dc.contributor.author Marco Jiménez, Francisco es_ES
dc.contributor.author Vicente Antón, José Salvador es_ES
dc.date.accessioned 2017-02-21T13:03:44Z
dc.date.available 2017-02-21T13:03:44Z
dc.date.issued 2014-04-15
dc.identifier.issn 0093-691X
dc.identifier.uri http://hdl.handle.net/10251/78120
dc.description.abstract The short-term effects of cryopreservation and embryo transfer are well documented (reduced embryo viability, changes in pattern expression), but little is known about their long-term effects. We examined the possibility that embryo vitrification and transfer in rabbit could have an impact on the long-term reproductive physiology of the offspring and whether these phenotypes could be transferred to the progeny. Vitrified rabbit embryos were warmed and transferred to recipient females (F0). The offspring of the F0 generation were the F1 generation (cryopreserved animals). Females from F1 generation offspring were bred to F1 males to generate an F2 generation. In addition, two counterpart groups of noncryopreserved animals were bred and housed simultaneously to F1 and F2 generations (CF1 and CF2, respectively). The reproductive traits studied in all studied groups were litter size (LS), number born alive at birth (BA), and postnatal survival at Day 28 (number of weaned/number born alive expressed as percentage). The reproductive traits were analyzed using Bayesian methodology. Features of the estimated marginal posterior distributions of the differences between F1 and their counterparts (F1 - CF1) and between F2 and their counterparts (F2 - CF2) in reproductive characters found that vitrification and transfer procedures cause a consistent increase in LS and BA between F1 and CF1 females (more than 1.4 kits in LS and more than 1.3 BA) and also between F2 and CF2 females (0.96 kits in LS and 0.94 BA). We concluded that embryo cryopreservation and transfer procedures have long-term effects on derived female reproduction (F1 females) and transgenerational effects on female F1 offspring (F2 females). es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Theriogenology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Long-term effect es_ES
dc.subject Transgenerational es_ES
dc.subject Cryopreservation es_ES
dc.subject Maternal effect es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title Long-term and transgenerational effects of cryopreservation on rabbit embryos es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.theriogenology.2014.01.030
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Ciencia y Tecnología Animal - Institut de Ciència i Tecnologia Animal es_ES
dc.description.bibliographicCitation Lavara García, R.; Baselga Izquierdo, M.; Marco Jiménez, F.; Vicente Antón, JS. (2014). Long-term and transgenerational effects of cryopreservation on rabbit embryos. Theriogenology. 81(7):988-992. doi:10.1016/j.theriogenology.2014.01.030 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi.org/ 10.1016/j.theriogenology.2014.01.030 es_ES
dc.description.upvformatpinicio 988 es_ES
dc.description.upvformatpfin 992 es_ES
dc.type.version info:eu repo/semantics/publishedVersion es_ES
dc.description.volume 81 es_ES
dc.description.issue 7 es_ES
dc.relation.senia 262044 es_ES


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