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dc.contributor.author | Sánchez-Velázquez, Patricia![]() |
es_ES |
dc.contributor.author | Castellví, Quim![]() |
es_ES |
dc.contributor.author | Villanueva, A![]() |
es_ES |
dc.contributor.author | Quesada, Rita![]() |
es_ES |
dc.contributor.author | Pañella, C.![]() |
es_ES |
dc.contributor.author | Cáceres, Marta![]() |
es_ES |
dc.contributor.author | Dorcaratto, Dimitri![]() |
es_ES |
dc.contributor.author | Andaluz, Anna![]() |
es_ES |
dc.contributor.author | Moll, X.![]() |
es_ES |
dc.contributor.author | Trujillo Guillen, Macarena![]() |
es_ES |
dc.contributor.author | Burdío Pinilla, José Miguel![]() |
es_ES |
dc.contributor.author | Berjano Zanón, Enrique![]() |
es_ES |
dc.contributor.author | Grande, Luis![]() |
es_ES |
dc.contributor.author | Ivorra, A.![]() |
es_ES |
dc.contributor.author | Burdío Pinilla, Fernando![]() |
es_ES |
dc.date.accessioned | 2017-02-28T18:37:06Z | |
dc.date.available | 2017-02-28T18:37:06Z | |
dc.date.issued | 2016-04-01 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10251/78377 | |
dc.description.abstract | Irreversible electroporation is a fast-growing liver ablation technique. Although safety has been well documented in small ablations, our aim is to assess its safety and feasibility when a large portion of liver is ablated. Eighty-seven mice were subjected to high voltage pulses directly delivered across parallel plate electrodes comprising around 40% of mouse liver. One group consisted in 55 athymicnude, in which a tumor from the KM12C cell line was grown and the other thirty-two C57-Bl6 nontumoral mice. Both groups were subsequently divided into subsets according to the delivered field strength (1000V/cm, 2000V/cm) and whether or not they received anti-hyperkalemia therapy. Early mortality (less than 24hours post-IRE) in the 2000V/cm group was observed and revealed considerably higher mean potassium levels. In contrast, the animals subjected to a 2000V/cm field treated with the anti-hyperkalemia therapy had higher survival rates (OR=0.1, 95%CI=0.02–0.32, p<0.001). Early mortality also depended on the electric field magnitude of the IRE protocol, as mice given 1000V/cm survived longer than those given 2000V/cm (OR=4.7, 95%CI=1.8–11.8, p=0.001). Our findings suggest that ionic disturbances, mainly due to potassium alterations, should be warned and envisioned when large volume ablations are performed by IRE. | es_ES |
dc.description.sponsorship | This research was supported by the Spanish "Plan Estatal de Investigacion, Desarrollo e Innovacion Orientada a los Retos de la Sociedad" under Grant TEC2014-52383-C3 (TEC2014-52383-C3-1-R, TEC2014-52383-C3-2-R, and TEC2014-52383-C3-3-R), and by the Spanish "Plan Nacional de I + D + i del Ministerio de Ciencia e Innovacion" under Grants TEC2011-27133-C02 and TEC2010-17285. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.relation.ispartof | Scientific Reports | es_ES |
dc.rights | Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) | es_ES |
dc.subject.classification | INGENIERIA MECANICA | es_ES |
dc.subject.classification | MATEMATICA APLICADA | es_ES |
dc.subject.classification | TECNOLOGIA ELECTRONICA | es_ES |
dc.title | Irreversible electroporation of the liver: is there a safe limit to the ablation volume? | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1038/srep23781 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//TEC2014-52383-C3-3-R/ES/VALORACION EXPERIMENTAL IN VIVO DE TECNOLOGIAS BASADAS EN ENERGIA ELECTROMAGNETICA PARA CIRUGIA DE MINIMA INVASION/ / | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//TEC2010-17285/ES/METODOS Y HERRAMIENTAS PARA LA ELECTROPORACION IN VIVO/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//TEC2011-27133-C02-01/ES/MODELADO TEORICO Y EXPERIMENTACION PARA TECNICAS ABLATIVAS BASADAS EN ENERGIA/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//TEC2014-52383-C3-1-R/ES/TECNOLOGIAS BASADAS EN ENERGIA DE RADIOFRECUENCIA Y MICROONDAS PARA CIRUGIA DE MINIMA INVASION/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//TEC2014-52383-C3-2-R/ES/TECNOLOGIAS BASADAS EN ELECTROPORACION PARA CIRUGIA DE MINIMA INVASION/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Arquitectura - Escola Tècnica Superior d'Arquitectura | es_ES |
dc.description.bibliographicCitation | Sánchez-Velázquez, P.; Castellví, Q.; Villanueva, A.; Quesada, R.; Pañella, C.; Cáceres, M.; Dorcaratto, D.... (2016). Irreversible electroporation of the liver: is there a safe limit to the ablation volume?. Scientific Reports. 6(23781):1-7. doi:10.1038/srep23781 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1038/srep23781 | es_ES |
dc.description.upvformatpinicio | 1 | es_ES |
dc.description.upvformatpfin | 7 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 6 | es_ES |
dc.description.issue | 23781 | es_ES |
dc.relation.senia | 305512 | es_ES |
dc.identifier.pmid | 27032535 | en_EN |
dc.identifier.pmcid | PMC4817133 | en_EN |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |
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