- -

Anti-diabetic and anti-obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

Anti-diabetic and anti-obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition

Show full item record

Rodríguez Hernández, CJ.; Guinovart, J.; Murguía, JR. (2012). Anti-diabetic and anti-obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition. FEBS Letters. 586(3):270-276. doi:10.1016/j.febslet.2011.12.035

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/78514

Files in this item

Item Metadata

Title: Anti-diabetic and anti-obesity agent sodium tungstate enhances GCN pathway activation through Glc7p inhibition
Author:
UPV Unit: Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes
Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural
Issued date:
Abstract:
[EN] Tungstate counteracts diabetes and obesity in animal models, but its molecular mechanisms remain elusive. Our Saccharomyces cerevisiae-based approach has found that tungstate alleviated the growth defect induced by ...[+]
Subjects: Tungstate , Translational control , Phosphatase , Diabetes , Nutrient stress
Copyrigths: Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
Source:
FEBS Letters. (issn: 0014-5793 ) (eissn: 1873-3468 )
DOI: 10.1016/j.febslet.2011.12.035
Publisher:
Elsevier
Wiley
Publisher version: http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2011.12.035/full
Thanks:
We thank R. Serrano for providing the Delta cnb1 mutant strain. We thank A. G. Hinnebusch for the gcn2-507 and gcn2 mutant strains. The pGEX-GLC7 plasmid was kindly provided by P. Sanz. The PP1-FLAG construct was kindly ...[+]
Type: Artículo

This item appears in the following Collection(s)

Show full item record