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The insecticide DDT targets the OSCP and subunit D of the Apis mellifera ATP synthase

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The insecticide DDT targets the OSCP and subunit D of the Apis mellifera ATP synthase

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dc.contributor.author Younis, Hassan M. es_ES
dc.contributor.author Serrano Salom, Ramón es_ES
dc.contributor.author Abdel Razik, Reda K. es_ES
dc.contributor.author Rydström, Jan es_ES
dc.date.accessioned 2017-03-08T08:09:35Z
dc.date.available 2017-03-08T08:09:35Z
dc.date.issued 2011-10
dc.identifier.issn 0145-479X
dc.identifier.uri http://hdl.handle.net/10251/78576
dc.description.abstract 1, 1-bis (p-Chlorophenyl) -2, 2, 2-trichloroethane (DDT) has been used for control of malaria mosquitoes and other insect vectors of human diseases since 1945. Its use poses an environmental dilemma and efforts to replace it have been hampered by lack of information about its molecular target. This work identifies the 23 kDa band responsible for the DDT sensitivity in bees, as the OSCP and subunit "d" of the ATP synthase. The OSCP of the bee's ATP synthase contained 207 amino acids compared to 190 in bovine, which is insensitive to DDT, and the identities were only 47%. Subunit "d" of the bees had no counterpart in the bovine. Whether DDT is interacting only with OSCP, only with subunit "d", or with both subunits, remains to be assessed. Identification of the molecular target of DDT will lead the way to new target based insecticides aimed to protect plant, combat malaria and other insect transmitted diseases. es_ES
dc.description.sponsorship This work was supported by grant Dnr nr 348-2004-4977 from the Swedish Research Council. en_EN
dc.language Inglés es_ES
dc.publisher Springer Verlag (Germany) es_ES
dc.relation.ispartof Journal of Bioenergetics and Biomembranes es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Mass spectrometry es_ES
dc.subject DDT target es_ES
dc.subject ATP synthase es_ES
dc.subject Subunit "d" es_ES
dc.subject OSCP es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title The insecticide DDT targets the OSCP and subunit D of the Apis mellifera ATP synthase es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s10863-011-9378-z
dc.relation.projectID info:eu-repo/grantAgreement/VR//348-2004-4977/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Younis, HM.; Serrano Salom, R.; Abdel Razik, RK.; Rydström, J. (2011). The insecticide DDT targets the OSCP and subunit D of the Apis mellifera ATP synthase. Journal of Bioenergetics and Biomembranes. 43:457-463. https://doi.org/10.1007/s10863-011-9378-z es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://link.springer.com/article/10.1007/s10863-011-9378-z es_ES
dc.description.upvformatpinicio 457 es_ES
dc.description.upvformatpfin 463 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 43 es_ES
dc.relation.senia 218512 es_ES
dc.identifier.eissn 1573-6881
dc.contributor.funder Swedish Research Council es_ES
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