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Genotyping of single nucleotide polymorphisms related to attention-deficit hyperactivity disorder

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Genotyping of single nucleotide polymorphisms related to attention-deficit hyperactivity disorder

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dc.contributor.author Tortajada-Genaro, Luis Antonio es_ES
dc.contributor.author Mena-Mollá, Salvador es_ES
dc.contributor.author Niñoles Rodenes, Regina es_ES
dc.contributor.author Puigmule, Marta es_ES
dc.contributor.author Viladevall, Laia es_ES
dc.contributor.author Maquieira Catala, Ángel es_ES
dc.date.accessioned 2017-03-13T08:06:35Z
dc.date.available 2017-03-13T08:06:35Z
dc.date.issued 2016-03
dc.identifier.issn 1618-2642
dc.identifier.uri http://hdl.handle.net/10251/78688
dc.description.abstract Pharmacological treatment of several diseases, such as attention-deficit hyperactivity disorder (ADHD), presents marked variability in efficiency and its adverse effects. The genotyping of specific single nucleotide polymorphisms (SNPs) can support the prediction of responses to drugs and the genetic risk of presenting comorbidities associated with ADHD. This study presents two rapid and affordable microarray-based strategies to discriminate three clinically important SNPs in genes ADRA2A, SL6CA2, and OPRM1 (rs1800544, rs5569, and rs1799971, respectively). These approaches are allele-specific oligonucleotide hybridization (ASO) and a combination of allele-specific amplification (ASA) and solid-phase hybridization. Buccal swab and blood samples taken from ADHD patients and controls were analyzed by ASO, ASA, and a gold-reference method. The results indicated that ASA is superior in genotyping capability and analytical performance. es_ES
dc.description.sponsorship This research has been funded through projects FEDER MINECO INNPACTO IPT-2011-1132-010000, CTQ/2013/45875R, and PrometeoII/2014/040 (GVA). en_EN
dc.language Inglés es_ES
dc.publisher Springer Verlag (Germany) es_ES
dc.relation.ispartof Analytical and Bioanalytical Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject SNP genotyping es_ES
dc.subject Low-cost microarray technology es_ES
dc.subject Pharmacogenetics es_ES
dc.subject Attention-deficit hyperactivity disorder es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title Genotyping of single nucleotide polymorphisms related to attention-deficit hyperactivity disorder es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s00216-016-9332-3
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//IPT-2011-1132-010000/ES/Desarrollo de nueva tecnología para la realización de arrays de ADN/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO%2F2010%2F040/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//CTQ2013-45875-R/ES/BIOSENSADO EN SOPORTES INTERACTIVOS CON PROPIEDADES INTERFEROMETRICAS PARA APLICACIONES CLINICAS. DEMOSTRACION EN FARMACOGENETICA Y ALERGIAS MEDICAMENTOSAS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.description.bibliographicCitation Tortajada-Genaro, LA.; Mena-Mollá, S.; Niñoles Rodenes, R.; Puigmule, M.; Viladevall, L.; Maquieira Catala, Á. (2016). Genotyping of single nucleotide polymorphisms related to attention-deficit hyperactivity disorder. Analytical and Bioanalytical Chemistry. 408(9):2339-2345. https://doi.org/10.1007/s00216-016-9332-3 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1007/s00216-016-9332-3 es_ES
dc.description.upvformatpinicio 2339 es_ES
dc.description.upvformatpfin 2345 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 408 es_ES
dc.description.issue 9 es_ES
dc.relation.senia 314344 es_ES
dc.identifier.eissn 1618-2650
dc.contributor.funder Generalitat Valenciana es_ES
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