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Acetylcholinesterase-Capped Mesoporous Silica Nanoparticles That Open in the Presence of Diisopropylfluorophosphate (a Sarin or Soman Simulant)

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Acetylcholinesterase-Capped Mesoporous Silica Nanoparticles That Open in the Presence of Diisopropylfluorophosphate (a Sarin or Soman Simulant)

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Pascual, L.; El Sayed Shehata Nasr, S.; Martínez-Máñez, R.; Costero Nieto, AM.; Gil Grau, S.; Gaviña Costero, P.; Sancenón Galarza, F. (2016). Acetylcholinesterase-Capped Mesoporous Silica Nanoparticles That Open in the Presence of Diisopropylfluorophosphate (a Sarin or Soman Simulant). Organic Letters. 18(21):5548-5551. doi:10.1021/acs.orglett.6b02793

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/78859

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Title: Acetylcholinesterase-Capped Mesoporous Silica Nanoparticles That Open in the Presence of Diisopropylfluorophosphate (a Sarin or Soman Simulant)
Author: Pascual, Lluís El Sayed Shehata Nasr, Sameh Martínez-Máñez, Ramón Costero Nieto, Ana María Gil Grau, Salvador Gaviña Costero, Pablo Sancenón Galarza, Félix
UPV Unit: Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials
Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
Universitat Politècnica de València. Departamento de Química - Departament de Química
Issued date:
Abstract:
Mesoporous silica nanoparticles loaded with rhodamine B and capped with acetylcholinesterase are able to be selectively opened and deliver their cargo in the presence of nerve agent simulant diisopropyl fluorophosphate (DFP).[+]
Subjects: RESPONSIVE CONTROLLED-RELEASE , CHEMICAL WARFARE AGENTS , GUEST MOLECULES , GATED MATERIALS , DRUG-DELIVERY , DESIGN , DCNP , DNA , NANOCONTAINERS , NANOCAPSULES
Copyrigths: Cerrado
Source:
Organic Letters. (issn: 1523-7060 ) (eissn: 1523-7052 )
DOI: 10.1021/acs.orglett.6b02793
Publisher:
American Chemical Society
Publisher version: http://dx.doi. org/10.1021/acs.orglett.6b02793
Project ID:
Spanish Government and FEDER funds MAT2015-64139-C4-1
Generalitat Valenciana PROMETEOII/2014/047
Universitat Politecnica de Valencia
Thanks:
Financial support from the Spanish Government and FEDER funds (Project MAT2015-64139-C4-1) and the Generalitat Valenciana (Project PROMETEOII/2014/047) is gratefully acknowledged. L.P. is grateful to the Universitat ...[+]
Type: Artículo

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