dc.contributor.author |
De Munck, Lode
|
es_ES |
dc.contributor.author |
Vila, Carlos
|
es_ES |
dc.contributor.author |
Muñoz Roca, María del Carmen
|
es_ES |
dc.contributor.author |
Pedro, José R.
|
es_ES |
dc.date.accessioned |
2017-03-20T15:36:12Z |
|
dc.date.available |
2017-03-20T15:36:12Z |
|
dc.date.issued |
2016-12-05 |
|
dc.identifier.issn |
0947-6539 |
|
dc.identifier.uri |
http://hdl.handle.net/10251/78864 |
|
dc.description.abstract |
A catalytic highly enantioselective aza-Reformatsky
reaction with cyclic aldimines and ketimines for the
synthesis of chiral b-amino esters with good yields and excellent
enantioselectivities is reported.Areadily available
diaryl prolinol is used as a chiral ligand, ZnMe2 as a zinc
source and ethyl iodoacetate as reagent in the presence
of air atmosphere. The reaction with cyclic ketimines generates
a quaternary stereocenter with excellent levels of
enantioselectivity. Furthermore, five-membered N-sulfonyl
ketimines were used as electrophiles with good enantiomeric
excesses, under the optimized reaction conditions.
Moreover, several chemical transformations were performed
with the chiral b-amino esters. |
es_ES |
dc.description.sponsorship |
Financial support from the MINECO (Gobierno de Espana; CTQ2013-47494-P). L.D.M. thanks the Generalitat Valenciana for a predoctoral grant. C.V. thanks MINECO for a JdC contract. Access to NMR, MS and X-ray facilities from the Servei central de suport a la investigacio experimental (SCSIE)-UV is also acknowledged. |
en_EN |
dc.language |
Inglés |
es_ES |
dc.publisher |
Wiley |
es_ES |
dc.relation.ispartof |
Chemistry - A European Journal |
es_ES |
dc.rights |
Reserva de todos los derechos |
es_ES |
dc.subject |
Asymmetric catalysis |
es_ES |
dc.subject |
Cyclic ketimines |
es_ES |
dc.subject |
Reformatsky reaction |
es_ES |
dc.subject |
Zinc |
es_ES |
dc.subject |
Beta-amino ester |
es_ES |
dc.subject.classification |
FISICA APLICADA |
es_ES |
dc.title |
Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines |
es_ES |
dc.type |
Artículo |
es_ES |
dc.identifier.doi |
10.1002/chem.201604606 |
|
dc.relation.projectID |
info:eu-repo/grantAgreement/MINECO//CTQ2013-47494-P/ES/NUEVOS RETOS EN EL DESARROLLO DE PROCESOS ENANTIOSELECTIVOS DE FORMACION DE ENLACES C-C MEDIANTE CATALISIS DUAL COOPERATIVA./ |
es_ES |
dc.rights.accessRights |
Cerrado |
es_ES |
dc.contributor.affiliation |
Universitat Politècnica de València. Departamento de Física Aplicada - Departament de Física Aplicada |
es_ES |
dc.contributor.affiliation |
Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny |
es_ES |
dc.description.bibliographicCitation |
De Munck, L.; Vila, C.; Muñoz Roca, MDC.; Pedro, JR. (2016). Catalytic Enantioselective Aza-Reformatsky Reaction with Cyclic Imines. Chemistry - A European Journal. 22(49):17590-17594. https://doi.org/10.1002/chem.201604606 |
es_ES |
dc.description.accrualMethod |
S |
es_ES |
dc.relation.publisherversion |
http://dx.doi.org/10.1002/chem.201604606 |
es_ES |
dc.description.upvformatpinicio |
17590 |
es_ES |
dc.description.upvformatpfin |
17594 |
es_ES |
dc.type.version |
info:eu-repo/semantics/publishedVersion |
es_ES |
dc.description.volume |
22 |
es_ES |
dc.description.issue |
49 |
es_ES |
dc.relation.senia |
322587 |
es_ES |
dc.identifier.eissn |
1521-3765 |
|
dc.contributor.funder |
Ministerio de Economía y Competitividad |
es_ES |
dc.contributor.funder |
Generalitat Valenciana |
es_ES |