Diez, P.; Sanchez, A.; De La Torre Paredes, C.; Gamella, M.; Martínez-Ruíz, P.; Aznar, E.; Martínez-Máñez, R.... (2016). Neoglycoenzyme-Gated Mesoporous Silica Nanoparticles: Toward the Design of Nanodevices for Pulsatile Programmed Sequential Delivery. ACS Applied Materials and Interfaces. 8(12):7657-7665. doi:10.1021/acsami.5b12645
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/79084
Title:
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Neoglycoenzyme-Gated Mesoporous Silica Nanoparticles: Toward the Design of Nanodevices for Pulsatile Programmed Sequential Delivery
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Author:
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Diez, Paula
Sanchez, Alfredo
De la Torre Paredes, Cristina
Gamella, Maria
Martínez-Ruíz, Paloma
Aznar, Elena
Martínez-Máñez, Ramón
Pingarron, José M.
Villalonga, Reynaldo
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UPV Unit:
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Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials
Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
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Issued date:
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Abstract:
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We report herein the design of a stimulus-programmed pulsatile delivery system for sequential cargo release based on the use of a lactose-modified esterase as a capping agent in phenylboronic acid functionalized mesoporous ...[+]
We report herein the design of a stimulus-programmed pulsatile delivery system for sequential cargo release based on the use of a lactose-modified esterase as a capping agent in phenylboronic acid functionalized mesoporous silica nanoparticles. The dual-release mechanism was based on the distinct stability of the cyclic boronic acid esters formed with lactose residues and the long naturally occurring glycosylation chains in the modified neoglycoenzyme. Cargo delivery in succession was achieved using glucose and ethyl butyrate as triggers.
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Subjects:
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Enzymes
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Mesoporous silica
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Delivery
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Nanoparticles
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Esterase
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Neoglycoenzyme
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Glucose
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Copyrigths:
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Cerrado |
Source:
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ACS Applied Materials and Interfaces. (issn:
1944-8244
)
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DOI:
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10.1021/acsami.5b12645
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Publisher:
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American Chemical Society
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Publisher version:
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http://dx.doi. org/10.1021/acsami.5b12645
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Project ID:
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Spanish Ministry of Science and Innovation CTQ2011-24355 CTQ2009-12650 CTQ2009-09351 MAT2012-38429-004-01
Comunidad de Madrid S2009/PPQ-1642
Generalitat Valencia PROMETEOII/2014/047
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Thanks:
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R.V. acknowledges to Ramon & Cajal contract from the Spanish Ministry of Science and Innovation. Financial support from the Spanish Ministry of Science and Innovation (CTQ2011-24355, CTQ2009-12650, CTQ2009-09351, and ...[+]
R.V. acknowledges to Ramon & Cajal contract from the Spanish Ministry of Science and Innovation. Financial support from the Spanish Ministry of Science and Innovation (CTQ2011-24355, CTQ2009-12650, CTQ2009-09351, and MAT2012-38429-004-01) and Comunidad de Madrid (S2009/PPQ-1642), programme AVANSENS, is gratefully acknowledged. The Generalitat Valencia (project PROMETEOII/2014/047) is also acknowledged.
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Type:
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Artículo
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