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dc.contributor.author | Jornet Olivé, Mª Dolors | es_ES |
dc.contributor.author | Castillo López, Mª Ángeles | es_ES |
dc.contributor.author | Sabater Marco, Consuelo | es_ES |
dc.contributor.author | R. Domingo, Luis | es_ES |
dc.contributor.author | Tormos Faus, Rosa Esperanza | es_ES |
dc.contributor.author | Miranda Alonso, Miguel Ángel | es_ES |
dc.date.accessioned | 2017-03-27T10:44:32Z | |
dc.date.available | 2017-03-27T10:44:32Z | |
dc.date.issued | 2013-07-15 | |
dc.identifier.issn | 1010-6030 | |
dc.identifier.uri | http://hdl.handle.net/10251/79099 | |
dc.description.abstract | Fenbendazole (1) is a common veterinary anthelmintic, toxic to water living microorganisms. Fluorescence quantum yields of 1 were found to be 0.11 in acetonitrile, 0.068 in methanol, 0.034 in cyclohexane, and 0.013 in water. The singlet excited state energy was ca. 96 kcal mol(-1) in all solvents. The phosphorescence spectrum of 1 in ethanol at 77 K displayed a maximum at 450 nm, leading to a triplet energy of 75 kcal mol(-1). Experimental excited state energies agree well with the results of OFT calculations at the time-dependent B3LYP/6-311+G(d,p)//B3LYP/6-31G(d) level. Laser flash photolysis (LFP) of 1 at 266 nm led to transients absorbing in the 300-700 nm range, ascribed to radical cation 1(.+), which were also observed upon 355 nm LFP of xanthone (XA) in the presence of 1. Solar-simulated photolysis revealed XA-enhanced photodegradation of 1 and led to decreased toxicity, as shown by Daphnia magna assays. (c) 2013 Elsevier B.V. All rights reserved. | es_ES |
dc.description.sponsorship | Financial support from the MICINN (CTQ2010-19909) and the Generalitat Valenciana (Prometeo Program) is gratefully acknowledged. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Journal of Photochemistry and Photobiology A: Chemistry | es_ES |
dc.rights | Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) | es_ES |
dc.subject | Daphnia magna | es_ES |
dc.subject | Environmental remediation | es_ES |
dc.subject | Fenbendazole | es_ES |
dc.subject | Photodegradation | es_ES |
dc.subject | Toxicity | es_ES |
dc.subject.classification | MICROBIOLOGIA | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.subject.classification | BIOQUIMICA Y BIOLOGIA MOLECULAR | es_ES |
dc.title | Xanthone-photosensitized detoxification of the veterinary anthelmintic fenbendazole | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.jphotochem.2013.05.002 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//CTQ2010-19909/ES/MECANISMOS IMPLICADOS EN LA FOTO-REACTIVIDAD ENTRE FARMACOS CON PROPIEDADES ANTINEOPLASICAS Y SUS BIOMOLECULAS DIANA/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural | es_ES |
dc.description.bibliographicCitation | Jornet Olivé, MD.; Castillo López, MÁ.; Sabater Marco, C.; R. Domingo, L.; Tormos Faus, RE.; Miranda Alonso, MÁ. (2013). Xanthone-photosensitized detoxification of the veterinary anthelmintic fenbendazole. Journal of Photochemistry and Photobiology A: Chemistry. 264:34-40. https://doi.org/10.1016/j.jphotochem.2013.05.002 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.jphotochem.2013.05.002 | es_ES |
dc.description.upvformatpinicio | 34 | es_ES |
dc.description.upvformatpfin | 40 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 264 | es_ES |
dc.relation.senia | 253414 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |