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Quantitative approach to assist neuroblastoma assessment by measuring I-123 mIBG uptake in scintigraphic images

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Quantitative approach to assist neuroblastoma assessment by measuring I-123 mIBG uptake in scintigraphic images

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dc.contributor.author Martínez Díaz, Rafael es_ES
dc.contributor.author Balaguer Guill, Julia es_ES
dc.contributor.author Sánchez Ruiz, Luis Manuel es_ES
dc.contributor.author Bello Arques, Pilar es_ES
dc.contributor.author Castel, Victoria es_ES
dc.contributor.author Rivas Sanchez, Antonio es_ES
dc.contributor.author Cañete Nieto, Adela es_ES
dc.contributor.author Falgás Lacueva, Marina es_ES
dc.contributor.author Loaiza Gongora, Jose Luis es_ES
dc.contributor.author Peris Fajarnes, Guillermo es_ES
dc.date.accessioned 2017-03-28T15:08:34Z
dc.date.available 2017-03-28T15:08:34Z
dc.date.issued 2015
dc.identifier.issn 1580-3139
dc.identifier.uri http://hdl.handle.net/10251/79166
dc.description.abstract Whole-body 123I-Metaiodobenzylguanidine (mIBG) scintigraphy is used as the primary image modality in neuroblastoma detection. It is the most sensitive and specific method for staging and response evaluation. Validated semi-quantitative scoring methods with low interobserver variability and high reproducibility have shown to be indispensable for the evaluation of response to therapy. However, low resolution, noise and acquisition difficulties, specially in children, make low definition scans. These facts increase observer dependent interpretations that limit assessment and complicate to put a scoring method succesfully into practice. It is essential to have an objective and reliable measure of response to test the activity of therapies. In this paper we propose the use of a quantitative observer-independent measurement of the strength of uptake to be used as an additional tool for assisting the International Society of Paediatric Oncology Europe Neuroblastoma Group (SIOPEN) semi-quantitative scoring method. This is the scoring method recommended by the SIOPEN Nuclear Medicine and Physics Committee, in collaborative work with the Children’s Oncology Group, as the standard one for acquiring and reporting diagnostic paediatric mIBG scans across Europe. Our proposed method is based on the ratio between the amount of specific uptake at tumours and the amount of non-specific uptake at SIOPEN anatomical sectors which has shown to be constant in all the scans of the patients. es_ES
dc.description.sponsorship This work has been supported by "Ayudas para Actividades Preparatorias de Proyectos Coordinados entre Investigadores de la Universitat Politecnica de Valencia e Investigadores del Hospital Universitario y Politecnico La Fe", II Call, 2013, AUTOSCOREMIBG project. The authors are very grateful to the referees for their useful comments. en_EN
dc.language Inglés es_ES
dc.publisher International Society for Stereology & Image Analysis es_ES
dc.relation.ispartof Image Analysis and Stereology es_ES
dc.rights Reconocimiento - No comercial (by-nc) es_ES
dc.subject Image analysis es_ES
dc.subject mIBG es_ES
dc.subject Neuroblastoma es_ES
dc.subject Quantitative assessment es_ES
dc.subject Scintigraphy es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.subject.classification EXPRESION GRAFICA EN LA INGENIERIA es_ES
dc.title Quantitative approach to assist neuroblastoma assessment by measuring I-123 mIBG uptake in scintigraphic images es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.5566/ias.1219
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Geodésica, Cartográfica y Topográfica - Escola Tècnica Superior d'Enginyeria Geodèsica, Cartogràfica i Topogràfica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation Martínez Díaz, R.; Balaguer Guill, J.; Sánchez Ruiz, LM.; Bello Arques, P.; Castel, V.; Rivas Sanchez, A.; Cañete Nieto, A.... (2015). Quantitative approach to assist neuroblastoma assessment by measuring I-123 mIBG uptake in scintigraphic images. Image Analysis and Stereology. 34(2):135-144. doi:10.5566/ias.1219 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.5566/ias.1219 es_ES
dc.description.upvformatpinicio 135 es_ES
dc.description.upvformatpfin 144 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 34 es_ES
dc.description.issue 2 es_ES
dc.relation.senia 290173 es_ES
dc.identifier.eissn 1854-5165
dc.contributor.funder Hospital Universitari i Politècnic La Fe
dc.contributor.funder Universitat Poltècnica de València


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