- -

Anions as Triggers in Controlled Release Protocols from Mesoporous Silica Nanoparticles Functionalized with Macrocyclic Copper(II) Complexes

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

  • Estadisticas de Uso

Anions as Triggers in Controlled Release Protocols from Mesoporous Silica Nanoparticles Functionalized with Macrocyclic Copper(II) Complexes

Show simple item record

Files in this item

dc.contributor.author El Sayed Shehata Nasr, Sameh es_ES
dc.contributor.author Milani, Michele es_ES
dc.contributor.author Milanese,Chiara es_ES
dc.contributor.author Licchelli, Maurizio es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.date.accessioned 2017-04-04T15:31:52Z
dc.date.available 2017-04-04T15:31:52Z
dc.date.issued 2016-09
dc.identifier.issn 0947-6539
dc.identifier.uri http://hdl.handle.net/10251/79448
dc.description.abstract Three different mesoporous silica nano-sized materials (SC1, SC2, and SC3), loaded with [Ru(bipy)(3)](2+) dye (bipy= bipyridine) and functionalized on the external surface with three macrocyclic copper(II) complexes (C1, C2, and C3), were synthesized and characterized. When SC1, SC2, and SC3 were suspended in water, the entrapped [Ru(bipy)(3)](2+) dye was free to diffuse from the inner pores to the solution. However, addition of anions induced certain degrees of pore blockage, with subsequent dye release inhibition. Small monovalent and divalent anions were unable to induce complete pore blockage, whereas bulky and highly charged anions induced marked reductions in [Ru(bipy)(3)](2+) delivery. The best [Ru(bipy)(3)](2+) delivery inhibitors were ATP and hexametaphosphate anions. Inhibition was ascribed to the interaction of the anions with the grafted Cu-II complexes on the surface of the SC1, SC2, and SC3 supports. The hexametaphosphate anion was selected to prepare two capped materials (SC1-mPh and SC3-mPh). Studies of the [Ru(bipy)(3)](2+) dye release from solids SC1-mPh and SC3-mPh alone and in the presence of a collection of selected anions (HS-, F-, Br-, Cl-, I-, CN-, HPO42-, AcO-, citrate, NO32-, HCO3-, SO42-, and S2O82-), amino acids (alanine and histidine), thiol-containing biomolecules (cysteine, methylcysteine, homocysteine, and glutathione (GSH)), and oxidants (H2O2) were performed. None of the chemicals tested, except hydrogen sulphide, was able to induce remarkable cargo delivery in both solids. The observed dye release was ascribed to a demetalation reaction of the C1 and C3 complexes induced by the hydrogen sulphide anion. es_ES
dc.description.sponsorship Financial support from the Spanish Government (Project MAT2012-38429-C04-01) and the Generalitat Valencia (Project PROMETEO/2009/016) is gratefully acknowledged. en_EN
dc.language Inglés es_ES
dc.publisher Wiley es_ES
dc.relation.ispartof Chemistry - A European Journal es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject anion-controlled release es_ES
dc.subject copper es_ES
dc.subject fluorescence es_ES
dc.subject hydrogen sulphide es_ES
dc.subject mesoporous nanoparticles es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Anions as Triggers in Controlled Release Protocols from Mesoporous Silica Nanoparticles Functionalized with Macrocyclic Copper(II) Complexes es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/chem.201601024
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2012-38429-C04-01/ES/DESARROLLO DE MATERIALES FUNCIONALIZADOS CON PUERTAS NANOSCOPICAS PARA APLICACIONES DE LIBERACION CONTROLADA Y SENSORES PARA LA DETECCION DE NITRATO AMONICO, SULFIDRICO Y CO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/Generalitat Valenciana//PROMETEO09%2F2009%2F016/ES/Ayuda prometeo 2009 para el grupo de diseño y desarrollo de sensores/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.description.bibliographicCitation El Sayed Shehata Nasr, S.; Milani, M.; Milanese, C.; Licchelli, M.; Martínez-Máñez, R.; Sancenón Galarza, F. (2016). Anions as Triggers in Controlled Release Protocols from Mesoporous Silica Nanoparticles Functionalized with Macrocyclic Copper(II) Complexes. Chemistry - A European Journal. 22(39):13935-13945. https://doi.org/10.1002/chem.201601024 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1002/chem.201601024 es_ES
dc.description.upvformatpinicio 13935 es_ES
dc.description.upvformatpfin 13945 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 22 es_ES
dc.description.issue 39 es_ES
dc.relation.senia 318225 es_ES
dc.identifier.eissn 1521-3765
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES


This item appears in the following Collection(s)

Show simple item record