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Design and evaluation of the MAMMI dedicated breast PET

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Design and evaluation of the MAMMI dedicated breast PET

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dc.contributor.author Moliner Martínez, Laura es_ES
dc.contributor.author González Martínez, Antonio Javier es_ES
dc.contributor.author Soriano Asensi, Antonio es_ES
dc.contributor.author Sánchez Martínez, Filomeno es_ES
dc.contributor.author Correcher Salvador, Carlos es_ES
dc.contributor.author Orero Palomares, Abel es_ES
dc.contributor.author Carles Fariña, Montserrat es_ES
dc.contributor.author Vidal San Sebastián, Luis Fernando es_ES
dc.contributor.author Barberá Ballester, Julio es_ES
dc.contributor.author Caballero Ontanaya, Luis es_ES
dc.contributor.author Seimetz, Michael es_ES
dc.contributor.author Vazquez Barreiros, Carlos es_ES
dc.contributor.author Benlloch Baviera, Jose María es_ES
dc.date.accessioned 2017-04-05T09:16:46Z
dc.date.issued 2012-09
dc.identifier.issn 0094-2405
dc.identifier.uri http://hdl.handle.net/10251/79469
dc.description.abstract Purpose: A breast dedicated positron emission tomography (PET) scanner has been developed based on monolithic LYSO crystals coupled to position sensitive photomultiplier tubes (PSPMTs). In this study, we describe the design of the PET system and report on its performance evaluation. Methods: MAMMI is a breast PET scanner based on monolithic LYSO crystals. It consists of 12 compact modules with a transaxial field of view (FOV) of 170 mm in diameter and 40 mm axial FOV that translates to cover up to 170 mm. The patient lies down in a prone position that facilitates maximum breast elongation. Quantitative performance analysis of the calculated method for the attenuation correction specifically developed for MAMMI, and based on PET image segmentation, has also been conducted in this evaluation. In order to fully determine the MAMMI prototype’s performance, we have adapted the measurements suggested for National Electrical Manufacturers Association (NEMA) NU 2-2007 and NU 4-2008 protocol tests, as they are defined for whole-body and small animal PET scanners, respectively. Results: Spatial resolutions of 1.6, 1.8, and 1.9 mm were measured in the axial, radial, and tangential directions, respectively. A scatter fraction of 20.8% was obtained and the maximum NEC was determined to be 25 kcps at 44 MBq. The average sensitivity of the system was observed to be 1% for an energy window of (250 keV–750 keV) and a maximum absolute sensitivity of 1.8% was measured at the FOV center. Conclusions: The overall performance of the MAMMI reported on this evaluation quantifies its ability to produce high quality PET images. Spatial resolution values below 3 mm were measured in most of the FOV. Only the radial component of spatial resolution exceeds the 3 mm at radial positions larger than 60 mm. This study emphasizes the need for standardized testing methodologies for dedicated breast PET systems similar to NEMA standards for whole-body and small animal PET scanners es_ES
dc.description.sponsorship This work was supported by the Spanish Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I+D+I) under Grant No. FIS2010-21216-CO2-01 and Valencian Local Government under Grant Nos. PROMETEO 2008/114 and APOSTD 2010/012. The authors would like to thank Teodor Dima and Brennan Holt for checking and correcting the text. en_EN
dc.language Inglés es_ES
dc.publisher American Association of Physicists in Medicine es_ES
dc.relation.ispartof Medical Physics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Breast PET es_ES
dc.subject Mammography es_ES
dc.subject Positron emission tomography es_ES
dc.title Design and evaluation of the MAMMI dedicated breast PET es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1118/1.4742850
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//FIS2010-21216-C02-01/ES/DESARROLLO DEL DETECTOR PET%2FRM PARA DIAGNOSTICO DE ENFERMEDADES NEURODEGENERATIVAS./ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEO08%2F2008%2F114/ES/Desarrollo de tecnología PET%2FRM para estudio cerebro en humanos/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//APOSTD%2F2010%2F012/ es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular es_ES
dc.description.bibliographicCitation Moliner Martínez, L.; González Martínez, AJ.; Soriano Asensi, A.; Sánchez Martínez, F.; Correcher Salvador, C.; Orero Palomares, A.; Carles Fariña, M.... (2012). Design and evaluation of the MAMMI dedicated breast PET. Medical Physics. 39(9):5393-5405. https://doi.org/10.1118/1.4742850 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1118/1.4742850 es_ES
dc.description.upvformatpinicio 5393 es_ES
dc.description.upvformatpfin 5405 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 39 es_ES
dc.description.issue 9 es_ES
dc.relation.senia 234475 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Generalitat Valenciana es_ES


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