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dc.contributor.author | Quesada-Diez, Rita | es_ES |
dc.contributor.author | Andaluz, Anna | es_ES |
dc.contributor.author | Cáceres, Marta | es_ES |
dc.contributor.author | Moll, Xavier | es_ES |
dc.contributor.author | Iglesias, Mar | es_ES |
dc.contributor.author | Dorcaratto, dimitri | es_ES |
dc.contributor.author | Poves, Ignasi | es_ES |
dc.contributor.author | Berjano, Enrique | es_ES |
dc.contributor.author | Grande, Luís | es_ES |
dc.contributor.author | Burdio Pinilla, Fernando | es_ES |
dc.date.accessioned | 2017-04-06T11:19:56Z | |
dc.date.available | 2017-04-06T11:19:56Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1424-3911 | |
dc.identifier.issn | 1424-3903 | |
dc.identifier.uri | http://hdl.handle.net/10251/79520 | |
dc.description.abstract | Background: Pancreatic duct ligation (PDL) has been used as a model of chronic pancreatitis and as a model to increase β-cell mass. However, studies in mice have demonstrated acinar regeneration after PDL, questioning the long-term validity of the model. We aim to elucidate whether RF-assisted transection (RFAT) of the main pancreatic duct is a reliable PDL model, both in short (ST, 1-month) and long-term (LT, 6-months) follow-ups. Methods: Eleven pigs were subjected to RFAT. Biochemical (serum/peripancreatic amylase and glucose) and histological changes (including a semiautomatic morphometric study of over 1000 images/pancreas and IHC analysis) were evaluated after ST or LT follow-up and also in fresh pancreas specimens that were used as controls for 1 (n=4) and 6 months (n=6). Results: The distal pancreas in the ST was characterized by areas of acinar-to-ductal metaplasia (56%) which were significantly reduced at LT (21%) by fibrotic replacement and adipose tissue. The endocrine mass showed a normal increase. Conclusion: RFAT in the pig seems to be an appropriate PDL model without restoration of pancreatic drainage or reduction of endocrine mass. | es_ES |
dc.description.sponsorship | "This work was supported by the Spanish "Plan Estatal de Investigacion, Desarrollo e Innovacion Orientada a los Retos de la Sociedad" under Grant TEC2014-52383-C3 (TEC2014-52383-C3-3-R). RQ, EB, FB declare stock ownership in Apeiron Medical S.L., a company that has a license for the patent US 8.303.584.B2, on which the device have been employed. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Pancreatology | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Acinar to ductal metaplasia | es_ES |
dc.subject | Duodenopancreatectomy | es_ES |
dc.subject | Radiofrequency assisted transection | es_ES |
dc.subject | Animal model | es_ES |
dc.subject.classification | TECNOLOGIA ELECTRONICA | es_ES |
dc.title | Long-term evolution of acinar-to-ductal metaplasia and b-cell mass after radiofrequency-assisted transection of the pancreas in a controlled large animal model | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.pan.2015.10.014 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//TEC2014-52383-C3-3-R/ES/VALORACION EXPERIMENTAL IN VIVO DE TECNOLOGIAS BASADAS EN ENERGIA ELECTROMAGNETICA PARA CIRUGIA DE MINIMA INVASION/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny | es_ES |
dc.description.bibliographicCitation | Quesada-Diez, R.; Andaluz, A.; Cáceres, M.; Moll, X.; Iglesias, M.; Dorcaratto, D.; Poves, I.... (2016). Long-term evolution of acinar-to-ductal metaplasia and b-cell mass after radiofrequency-assisted transection of the pancreas in a controlled large animal model. Pancreatology. 16:38-43. https://doi.org/10.1016/j.pan.2015.10.014 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.pan.2015.10.014 | es_ES |
dc.description.upvformatpinicio | 38 | es_ES |
dc.description.upvformatpfin | 43 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 16 | es_ES |
dc.relation.senia | 311814 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |