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dc.contributor.author | Mattiazzi Usaj, Mojca | es_ES |
dc.contributor.author | Prelec, Metod | es_ES |
dc.contributor.author | Brioznic, Mojca | es_ES |
dc.contributor.author | Primo Planta, Cecilia | es_ES |
dc.contributor.author | Curk, Tomaz | es_ES |
dc.contributor.author | Scancar, Janez | es_ES |
dc.contributor.author | Yenush, Lynne | es_ES |
dc.contributor.author | Petrovic, Uros | es_ES |
dc.date.accessioned | 2017-04-20T06:50:50Z | |
dc.date.available | 2017-04-20T06:50:50Z | |
dc.date.issued | 2015-09 | |
dc.identifier.issn | 1756-5901 | |
dc.identifier.uri | http://hdl.handle.net/10251/79835 | |
dc.description.abstract | [EN] The functional link between zinc homeostasis and membrane-related processes, including lipid metabolism regulation, extends from yeast to humans, and has a likely role in the pathogenesis of diabetes. The yeast Izh2 protein has been previously implicated in zinc ion homeostasis and in the regulation of lipid and phosphate metabolism, but its precise molecular function is not known. We performed a chemogenomics experiment to determine the genes conferring resistance or sensitivity to different environmental zinc concentrations. We then determined at normal, depleted and excess zinc concentrations, the genetic interactions of IZH2 at the genome-wide level and measured changes in the transcriptome caused by deletion of IZH2. We found evidence for an important cellular function of the Rim101 pathway in zinc homeostasis in neutral or acidic environments, and observed that phosphatidylinositol is a source of inositol when zinc availability is limited. Comparison of our experimental profiles with published gene expression and genetic interaction profiles revealed pleiotropic functions for Izh2. We propose that Izh2 acts as an integrator of intra- and extracellular signals in providing adequate cellular responses to maintain homeostasis under different external conditions, including but not limited to alterations in zinc concentrations. Guardar / Salir Siguiente > | es_ES |
dc.description.sponsorship | This work was supported by grant P1-0207 from the Slovenian Research Agency. M.M.U. was supported by the Young Investigator fellowship scheme from the Slovenian Research Agency. Work done in the group of L.Y. was funded by grant BFU2011-30197-C03-03 from the Spanish Ministry of Science and Innovation (Madrid, Spain). C.P. was supported by a pre-doctoral fellowship from the Spanish Research Council. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.relation.ispartof | Metallomics | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Adiponectin | es_ES |
dc.subject | Ph homeostasis | es_ES |
dc.subject | Zinc | es_ES |
dc.subject | Phospholipid | es_ES |
dc.subject.classification | BIOQUIMICA Y BIOLOGIA MOLECULAR | es_ES |
dc.title | Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1039/c5mt00095e | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BFU2011-30197-C03-03/ES/PAPEL DEL TRAFICO DE PROTEINAS EN LA HOMEOSTASIS DE IONES Y NUTRIENTES EN LEVADURA Y PLANTAS/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural | es_ES |
dc.description.bibliographicCitation | Mattiazzi Usaj, M.; Prelec, M.; Brioznic, M.; Primo Planta, C.; Curk, T.; Scancar, J.; Yenush, L.... (2015). Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis. Metallomics. 7(9):1338-1351. https://doi.org/10.1039/c5mt00095e | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://doi.org/10.1039/c5mt00095e | es_ES |
dc.description.upvformatpinicio | 1338 | es_ES |
dc.description.upvformatpfin | 1351 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 7 | es_ES |
dc.description.issue | 9 | es_ES |
dc.relation.senia | 293503 | es_ES |
dc.identifier.pmid | 26067383 | |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |