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Prediction of the in vivo mechanical behavior of biointegrable acrylic macroporous scaffolds

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Prediction of the in vivo mechanical behavior of biointegrable acrylic macroporous scaffolds

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dc.contributor.author Vikingsson, Line es_ES
dc.contributor.author Antolinos Turpín, Carmen María es_ES
dc.contributor.author Gómez-Tejedor, José Antonio es_ES
dc.contributor.author Gallego-Ferrer, Gloria es_ES
dc.contributor.author Gómez Ribelles, José Luís es_ES
dc.date.accessioned 2017-05-02T08:25:00Z
dc.date.available 2017-05-02T08:25:00Z
dc.date.issued 2016-04-01
dc.identifier.issn 0928-4931
dc.identifier.uri http://hdl.handle.net/10251/80292
dc.description.abstract [EN] This study examines a biocompatible scaffold series of random copolymer networks P(EA-HEA) made of Ethyl Acrylate, EA, and 2-Hydroxyl Ethyl Acrylate, HEA. The P(EA-HEA) scaffolds have been synthesized with varying crosslinking density and filled with a Poly(Vinyl Alcohol), PVA, to mimic the growing cartilaginous tissue during tissue repair. In cartilage regeneration the scaffold needs to have sufficient mechanical properties to sustain the compression in the joint and, at the same time, transmit mechanical signals to the cells for chondrogenic differentiation. Mechanical tests show that the elastic modulus increases with increasing crosslinking density of P(EA-HEA) scaffolds. The water plays an important role in the mechanical behavior of the scaffold, but highly depends on the crosslinking density of the proper polymer. Furthermore, when the scaffold with hydrogel is tested it can be seen that the modulus increases with increasing hydrogel density. Even so, the mechanical properties are inferior than those of the scaffolds with water filling the pores. The hydrogel inside the pores of the scaffolds facilitates the expulsion of water during compression and lowers the mechanical modulus of the scaffold. The P(EA-HEA) with PVA shows to be a good artificial cartilage model with mechanical properties close to native articular cartilage. es_ES
dc.description.sponsorship This work was funded by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2013-46467-C4-1-R (including the FEDER financial support). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The authors acknowledge the assistance and advice of Electron Microscopy Service of the UPV. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Materials Science and Engineering: C es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Poly(ethyl acrylate) (PEA) es_ES
dc.subject Poly(2-hydroxyl ethyl acrylate) (PHEA) es_ES
dc.subject Poly(Vinyl Alcohol) es_ES
dc.subject Freezing and thawing es_ES
dc.subject Mechanical properties es_ES
dc.subject Scaffold es_ES
dc.subject Electron Microscopy Service of the UPV
dc.subject.classification MAQUINAS Y MOTORES TERMICOS es_ES
dc.subject.classification FISICA APLICADA es_ES
dc.title Prediction of the in vivo mechanical behavior of biointegrable acrylic macroporous scaffolds es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.msec.2015.12.068
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.description.bibliographicCitation Vikingsson, L.; Antolinos Turpín, CM.; Gómez-Tejedor, JA.; Gallego-Ferrer, G.; Gómez Ribelles, JL. (2016). Prediction of the in vivo mechanical behavior of biointegrable acrylic macroporous scaffolds. Materials Science and Engineering: C. 61:651-658. https://doi.org/10.1016/j.msec.2015.12.068 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.msec.2015.12.068 es_ES
dc.description.upvformatpinicio 651 es_ES
dc.description.upvformatpfin 658 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 61 es_ES
dc.relation.senia 299174 es_ES
dc.contributor.funder Instituto de Salud Carlos III
dc.contributor.funder Ministerio de Economía y Competitividad


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