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The role of tumor-infiltrating immune cells and chronic inflammation at the tumor site on cancer development, progression, and prognosis: emphasis on non-small cell lung cancer

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The role of tumor-infiltrating immune cells and chronic inflammation at the tumor site on cancer development, progression, and prognosis: emphasis on non-small cell lung cancer

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dc.contributor.author Bremnes, Roy M. es_ES
dc.contributor.author Al-Shibli, Khalid es_ES
dc.contributor.author Donnem, Tom es_ES
dc.contributor.author Sirera Pérez, Rafael es_ES
dc.contributor.author Al-Saad, Samer es_ES
dc.contributor.author Andersen, Sigve es_ES
dc.contributor.author Stenvold, Helge es_ES
dc.contributor.author Camps, Carlos es_ES
dc.contributor.author Busund, Lill-Tove es_ES
dc.date.accessioned 2017-05-12T07:10:14Z
dc.date.available 2017-05-12T07:10:14Z
dc.date.issued 2011-04
dc.identifier.issn 1556-0864
dc.identifier.uri http://hdl.handle.net/10251/81032
dc.description.abstract [EN] In addition to malignant neoplastic cells, cancer tissues also include immune cells, fibroblasts, and endothelial cells, including an abundant collection of growth factors, proangiogenic mediators, cytokines, chemokines, and components of the extracellular matrix. The main physiological function of the immune cells is to monitor tissue homeostasis, to protect against invading pathogens, and to eliminate transformed or damaged cells. Between immune cells and malignant cells in the tumor stroma, there is in fact a complex interaction which has significant prognostic relevance as the immune system has both tumor-promoting and-inhibiting roles. In non-small cell lung cancer (NSCLC), there is a marked infiltration of different types of immune cells, and the distribution, tissue localization, and cell types are significantly associated with progression and survival. Cancer immunotherapy has seen a significant progress during the last decade. An increased understanding of the mechanisms by which lung cancer cells escape the immune system, and the recognition of the key tumor antigens and immune system components in tumor ignorance have led to the development of several lung cancer vaccines. As the NSCLC prognosis in general is dismal, one may hope that future immunotherapy may be an effective adjunct to standard therapy, reversing immunologic tolerance in the tumor microenvironment. This review reports on the tumor stroma and in particular tumor-suppressing and-promoting roles of the immune system. Furthermore, it presents recent literature on relevant immune cell-related research in NSCLC. Copyright © 2011 by the International Association for the Study of Lung Cancer. es_ES
dc.language Inglés es_ES
dc.publisher Lippincott, Williams & Wilkins es_ES
dc.relation.ispartof Journal of Thoracic Oncology es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Immune cells es_ES
dc.subject In situ immunology es_ES
dc.subject Lung cancer es_ES
dc.subject NSCLC es_ES
dc.subject Stroma es_ES
dc.subject Tumor es_ES
dc.subject Tumor microenvironment es_ES
dc.subject Adaptive immunity es_ES
dc.subject Article es_ES
dc.subject B lymphocyte es_ES
dc.subject Cancer growth es_ES
dc.subject Cancer immunotherapy es_ES
dc.subject Cancer invasion es_ES
dc.subject Cancer survival es_ES
dc.subject Carcinogenesis es_ES
dc.subject CD4+ T lymphocyte es_ES
dc.subject Cytotoxic T lymphocyte es_ES
dc.subject Dendritic cell es_ES
dc.subject Human es_ES
dc.subject Immunocompetent cell es_ES
dc.subject Immunological tolerance es_ES
dc.subject Inflammation es_ES
dc.subject Innate immunity es_ES
dc.subject Lung non small cell cancer es_ES
dc.subject Macrophage es_ES
dc.subject Mast cell es_ES
dc.subject Metastasis es_ES
dc.subject Natural killer T cell es_ES
dc.subject Priority journal es_ES
dc.subject Prognosis es_ES
dc.subject T lymphocyte es_ES
dc.subject Tumor localization es_ES
dc.subject Carcinoma, Non-Small-Cell Lung es_ES
dc.subject Chronic Disease es_ES
dc.subject Disease Progression es_ES
dc.subject Humans es_ES
dc.subject Lung Neoplasms es_ES
dc.subject Lymphocytes, Tumor-Infiltrating es_ES
dc.subject.classification MICROBIOLOGIA es_ES
dc.title The role of tumor-infiltrating immune cells and chronic inflammation at the tumor site on cancer development, progression, and prognosis: emphasis on non-small cell lung cancer es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1097/JTO.0b013e3182037b76
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Bremnes, RM.; Al-Shibli, K.; Donnem, T.; Sirera Pérez, R.; Al-Saad, S.; Andersen, S.; Stenvold, H.... (2011). The role of tumor-infiltrating immune cells and chronic inflammation at the tumor site on cancer development, progression, and prognosis: emphasis on non-small cell lung cancer. Journal of Thoracic Oncology. 6(4):824-833. doi:10.1097/JTO.0b013e3182037b76 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1097/JTO.0b013e3182037b76 es_ES
dc.description.upvformatpinicio 824 es_ES
dc.description.upvformatpfin 833 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 6 es_ES
dc.description.issue 4 es_ES
dc.relation.senia 221277 es_ES
dc.identifier.pmid 21173711


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