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A minimally invasive methodology based on morphometric parameters for day 2 embryo quality assessment

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A minimally invasive methodology based on morphometric parameters for day 2 embryo quality assessment

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dc.contributor.author Molina Botella, María Inmaculada es_ES
dc.contributor.author Lázaro Ibáñez, Elisa es_ES
dc.contributor.author Pertusa, José es_ES
dc.contributor.author Debón Aucejo, Ana María es_ES
dc.contributor.author Martinez Sanchis, Juan Vicente es_ES
dc.contributor.author Pellicer Bofill, Antonio Joaquin es_ES
dc.date.accessioned 2017-05-12T12:18:30Z
dc.date.available 2017-05-12T12:18:30Z
dc.date.issued 2014 es_ES
dc.identifier.issn 1472-6483 es_ES
dc.identifier.uri http://hdl.handle.net/10251/81087
dc.description.abstract [EN] The risk of multiple pregnancy to maternal fetal health can be minimized by reducing the number of embryos transferred. New tools for selecting embryos with the highest implantation potential should be developed. The aim of this study was to evaluate the ability of morphological and morphometric variables to predict implantation by analysing images of embryos. This was a retrospective study of 135 embryo photographs from 112 IVF ICSI cycles carried out between January and March 2011. The embryos were photographed immediately before transfer using Cronus 3 software. Their images were analysed using the public program ImageJ. Significant effects (P < 0.05), and higher discriminant power to predict implantation were observed for the morphometric embryo variables compared with morphological ones. The features for successfully implanted embryos were as follows: four cells on day 2 of development; all blastomeres with circular shape (roundness factor greater than 0.9), an average zona pellucida thickness of 13&#8201;µm and an average of 17695.1&#8201;µm2 for the embryo area. Embryo size, which is described by its area and the average roundness factor for each cell, provides two objective variables to consider when predicting implantation. This approach should be further investigated for its potential ability to improve embryo scoring. es_ES
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Reproductive BioMedicine Online es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Image analysis, embryo grading systems es_ES
dc.subject Logit regression es_ES
dc.subject Morphology es_ES
dc.subject Morphometry es_ES
dc.subject ROC curve es_ES
dc.subject.classification ESTADISTICA E INVESTIGACION OPERATIVA es_ES
dc.subject.classification PRODUCCION ANIMAL es_ES
dc.title A minimally invasive methodology based on morphometric parameters for day 2 embryo quality assessment
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.rbmo.2014.06.005 es_ES
dc.rights.accessRights Abierto
dc.contributor.affiliation Universitat Politècnica de València. Facultad de Administración y Dirección de Empresas - Facultat d'Administració i Direcció d'Empreses es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.description.bibliographicCitation Molina Botella, MI.; Lázaro Ibáñez, E.; Pertusa, J.; Debón Aucejo, AM.; Martinez Sanchis, JV.; Pellicer Bofill, AJ. (2014). A minimally invasive methodology based on morphometric parameters for day 2 embryo quality assessment. Reproductive BioMedicine Online. 29(4):470-480. doi:10.1016/j.rbmo.2014.06.005 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://doi.org/10.1016/j.rbmo.2014.06.005
dc.description.upvformatpinicio 470 es_ES
dc.description.upvformatpfin 480 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 29 es_ES
dc.description.issue 4 es_ES
dc.relation.senia 271936 es_ES
dc.identifier.eissn 1472-6491
dc.identifier.pmid 25154014


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