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Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1

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Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1

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Mena-Mollá, S.; Rodríguez, ML.; Ortega, Á.; Priego, S.; Obrador, E.; Asensi, M.; Petschen, I.... (2012). Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1. Journal of Translational Medicine. 10:1-13. doi:10.1186/1479-5876-10-8

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/81329

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Title: Glutathione and Bcl-2 targeting facilitates elimination by chemoradiotherapy of human A375 melanoma xenografts overexpressing bcl-xl, bcl-2, and mcl-1
Author:
UPV Unit: Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic
Issued date:
Abstract:
[EN] Background: Bcl-2 is believed to contribute to melanoma chemoresistance. However, expression of Bcl-2 proteins may be different among melanomas. Thus correlations among expression of Bcl-2-related proteins and in vivo ...[+]
Subjects: B16 melanoma , Cancer therapy , Metastatic melanoma , Antisense BCL-2 , In vitro , Cells , Mouse , Endothelium , Proteins , Family
Copyrigths: Reserva de todos los derechos
Source:
Journal of Translational Medicine. (issn: 1479-5876 )
DOI: 10.1186/1479-5876-10-8
Publisher:
BioMed Central
Publisher version: http://doi.org/10.1186/1479-5876-10-8
Thanks:
This research was supported by grants from the MICINN (SAF2009-07729 and IPT-010000-2010-21), Spain. M.L. Rodriguez held a fellowship from the MICINN.
Type: Artículo

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