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Stress hormones promote growth of B16-F10 melanoma metastases: an interleukin 6-and glutathione-dependent mechanism

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Stress hormones promote growth of B16-F10 melanoma metastases: an interleukin 6-and glutathione-dependent mechanism

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dc.contributor.author Valles, Soraya L. es_ES
dc.contributor.author Benlloch, Maria es_ES
dc.contributor.author Rodriguez , María Lucía es_ES
dc.contributor.author Mena-Mollá, Salvador es_ES
dc.contributor.author Pellicer, Jose A es_ES
dc.contributor.author Asensi-Miralles, Miguel Ángel es_ES
dc.contributor.author Obrador, Elena es_ES
dc.contributor.author Estrela, José María es_ES
dc.date.accessioned 2017-05-18T07:12:58Z
dc.date.available 2017-05-18T07:12:58Z
dc.date.issued 2013-03-22
dc.identifier.issn 1479-5876
dc.identifier.uri http://hdl.handle.net/10251/81330
dc.description.abstract [EN] Background: Interleukin (IL)-6 (mainly of tumor origin) activates glutathione (GSH) release from hepatocytes and its interorgan transport to B16-F10 melanoma metastatic foci. We studied if this capacity to overproduce IL-6 is regulated by cancer cell-independent mechanisms. Methods: Murine B16-F10 melanoma cells were cultured, transfected with red fluorescent protein, injected i.v. into syngenic C57BL/6J mice to generate lung and liver metastases, and isolated from metastatic foci using high-performance cell sorting. Stress hormones and IL-6 levels were measured by ELISA, and CRH expression in the brain by in situ hybridization. DNA binding activity of NF-kappa B, CREB, AP-1, and NF-IL-6 was measured using specific transcription factor assay kits. IL-6 expression was measured by RT-PCR, and silencing was achieved by transfection of anti-IL-6 small interfering RNA. GSH was determined by HPLC. Cell death analysis was distinguished using fluorescence microscopy, TUNEL labeling, and flow cytometry techniques. Statistical analyses were performed using Student's t test. Results: Plasma levels of stress-related hormones (adrenocorticotropin hormone, corticosterone, and noradrenaline) increased, following a circadian pattern and as compared to non-tumor controls, in mice bearing B16-F10 lung or liver metastases. Corticosterone and noradrenaline, at pathophysiological levels, increased expression and secretion of IL-6 in B16-F10 cells in vitro. Corticosterone- and noradrenaline-induced transcriptional up-regulation of IL-6 gene involves changes in the DNA binding activity of nuclear factor-kappa B, cAMP response element-binding protein, activator protein-1, and nuclear factor for IL-6. In vivo inoculation of B16-F10 cells transfected with anti-IL-6-siRNA, treatment with a glucocorticoid receptor blocker (RU-486) or with a beta-adrenoceptor blocker (propranolol), increased hepatic GSH whereas decreased plasma IL-6 levels and metastatic growth. Corticosterone, but not NORA, also induced apoptotic cell death in metastatic cells with low GSH content. Conclusions: Our results describe an interorgan system where stress-related hormones, IL-6, and GSH coordinately regulate metastases growth es_ES
dc.description.sponsorship This research was supported by grant (SAF2009-07729 and IPT-010000-2010-21) from the Ministerio de Economia y Competitividad (http://www.idi.mineco.gob.es), Spain.
dc.language Inglés es_ES
dc.publisher BioMed Central es_ES
dc.relation.ispartof Journal of Translational Medicine es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Metastases es_ES
dc.subject Glutathione es_ES
dc.subject Interleukin 6 es_ES
dc.subject Stress hormones es_ES
dc.subject Apoptosis es_ES
dc.title Stress hormones promote growth of B16-F10 melanoma metastases: an interleukin 6-and glutathione-dependent mechanism es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1186/1479-5876-11-72
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//SAF2009-07729/ES/Terapia Anti-Bcl-2 Y Deplecion De Gsh: Sensibilizacion Del Melanoma Maligno Humano A La Quimioradioterapia/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//IPT-010000-2010-021/ES/NANOCOMPLEJOS DE ARN SINTETICO COMO NUEVA TERAPIA CONTRA CÁNCERES AGRESIVOS PARA LOS QUE NO SE DISPONE DE TRATAMIENTO EFECTIVO/
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.description.bibliographicCitation Valles, SL.; Benlloch, M.; Rodriguez, ML.; Mena-Mollá, S.; Pellicer, JA.; Asensi-Miralles, MÁ.; Obrador, E.... (2013). Stress hormones promote growth of B16-F10 melanoma metastases: an interleukin 6-and glutathione-dependent mechanism. Journal of Translational Medicine. 11:1-14. https://doi.org/10.1186/1479-5876-11-72 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1186/1479-5876-11-72 es_ES
dc.description.upvformatpinicio 1 es_ES
dc.description.upvformatpfin 14 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 11 es_ES
dc.relation.senia 262535 es_ES
dc.identifier.eissn 23517603
dc.identifier.pmid 23517603 en_EN
dc.identifier.pmcid PMC3608962 en_EN
dc.contributor.funder Ministerio de Ciencia e Innovación
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