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Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations

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Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations

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Sardanyes Cayuela, J.; Simó, C.; Martínez, R.; Solé, RV.; Elena Fito, SF. (2014). Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations. Scientific Reports. (4):1-9. doi:10.1038/srep04625

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Título: Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
Autor: Sardanyes Cayuela, Jose Simó, Carles Martínez, Regina Solé, Ricard V. Elena Fito, Santiago Fco
Entidad UPV: Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes
Fecha difusión:
Resumen:
[EN] The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a ...[+]
Palabras clave: Single-nucleotide substitutions , Immunodeficiency-virus type-1 , Vesicular stomatitis-virus , Tobacco-ETCH-virus , Error threshold , RNA virus , Deleterious mutations , Muller ratchet , Human cancers , Evolution
Derechos de uso: Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
Fuente:
Scientific Reports. (issn: 2045-2322 )
DOI: 10.1038/srep04625
Editorial:
Nature Publishing Group
Versión del editor: http://doi.org/10.1038/srep04625
Agradecimientos:
We thank the members of the Complex Systems Lab as well as Phillip Gerrish, Susanna C. Manrubia, and Ernest Fontich for their helpful comments. The authors acknowledge the computing facilities of the Dynamical Systems Group ...[+]
Tipo: Artículo

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