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Effects of plasma rich in growth factors (PRGF) on biomechanicalproperties of Achilles tendon repair

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Effects of plasma rich in growth factors (PRGF) on biomechanicalproperties of Achilles tendon repair

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dc.contributor.author López-Nájera, Diego es_ES
dc.contributor.author Rubio-Zaragoza, Mónica es_ES
dc.contributor.author Sopena-Juncosa, Joaquín J. es_ES
dc.contributor.author Alentorn-Geli, Eduard es_ES
dc.contributor.author Cugat-Bertomeu, Ramón es_ES
dc.contributor.author Domínguez-Pérez, Juan M. es_ES
dc.contributor.author García-Balletbó, Montserrat es_ES
dc.contributor.author Primo Capella, Victor es_ES
dc.contributor.author Carrillo-Poveda, José M.
dc.date.accessioned 2017-05-23T07:00:40Z
dc.date.available 2017-05-23T07:00:40Z
dc.date.issued 2016-12
dc.identifier.issn 0942-2056
dc.identifier.uri http://hdl.handle.net/10251/81621
dc.description.abstract [EN] To assess the biomechanical effects of intra-tendinous injections of PRGF on the healing Achilles tendon after repair in a sheep model. Thirty sheep were randomly assigned into one of the six groups depending on the type of treatment received (PRGF or placebo) and survival time (2, 4 and 8 weeks). The Achilles tendon injury was repaired by suturing the tendinous edges employing a three-loop pulley pattern. A trans-articular external fixation system was then used for immobilization. The PRGF or placebo was administered on a weekly basis completing a maximum of three infiltrations. The force, section and tension values were compared between the operated and healthy Achilles tendons across all groups. The PRGF-treated tendons had higher force at 8 weeks compared with the placebo group (p = 0.007). Between 2 and 4 weeks, a significant increase in force in both the PRGF-treated tendon (p = 0.0027) and placebo group (p = 0.0095) occurred. No significant differences were found for section ratio between PRGF-treated tendons and the placebo group for any of the time periods evaluated. At 2 weeks, PRGF-treated tendons had higher tension ratio compared with placebo group tendons (p = 0.0143). Both PRGF and placebo treatments significantly improved the force (p < 0.001 and p = 0.0095, respectively) and tension (p = 0.009 and p = 0.0039, respectively) ratios at 8 weeks compared with 2 weeks. The application of PRGF increases Achilles tendon repair strength at 8 weeks compared with the use of placebo. The use of PRGF does not modify section and tension ratios compared with placebo at 8 weeks. The tension ratio progressively increases between 2 and 8 weeks compared with the placebo. es_ES
dc.language Inglés es_ES
dc.publisher Springer Verlag (Germany) es_ES
dc.relation.ispartof Knee Surgery, Sports Traumatology, Arthroscopy es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Plasma-rich growth factors es_ES
dc.subject PRGF es_ES
dc.subject PRP es_ES
dc.subject Achilles tendon repair es_ES
dc.subject Biomechanical properties es_ES
dc.title Effects of plasma rich in growth factors (PRGF) on biomechanicalproperties of Achilles tendon repair es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1007/s00167-015-3725-2
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biomecánica de Valencia - Institut Universitari Mixt de Biomecànica de València es_ES
dc.description.bibliographicCitation López-Nájera, D.; Rubio-Zaragoza, M.; Sopena-Juncosa, JJ.; Alentorn-Geli, E.; Cugat-Bertomeu, R.; Domínguez-Pérez, JM.; García-Balletbó, M.... (2016). Effects of plasma rich in growth factors (PRGF) on biomechanicalproperties of Achilles tendon repair. Knee Surgery, Sports Traumatology, Arthroscopy. 24(12):3997-4004. doi:10.1007/s00167-015-3725-2 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1007/s00167-015-3725-2 es_ES
dc.description.upvformatpinicio 3997 es_ES
dc.description.upvformatpfin 4004 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 24 es_ES
dc.description.issue 12 es_ES
dc.relation.senia 305937 es_ES
dc.identifier.eissn 1433-7347
dc.identifier.pmid 26272059
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