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dc.contributor.author | Ayala, Guillermo | es_ES |
dc.contributor.author | Diez, Fernando | es_ES |
dc.contributor.author | Gasso Matoses, María Teresa | es_ES |
dc.contributor.author | Jones, Brian E. | es_ES |
dc.contributor.author | Martin-Portugues, Rafae | es_ES |
dc.contributor.author | Ramiro-Aparicio, Juan | es_ES |
dc.date.accessioned | 2017-05-23T08:13:53Z | |
dc.date.available | 2017-05-23T08:13:53Z | |
dc.date.issued | 2016-04 | |
dc.identifier.issn | 0378-5173 | |
dc.identifier.uri | http://hdl.handle.net/10251/81638 | |
dc.description | This is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics 503 (2016) 36–40. DOI 10.1016/j.ijpharm.2016.02.017. | es_ES |
dc.description.abstract | The internal lubricant content (ILC) of inhalation grade HPMC capsules is a key factor to ensure good powder release when the patient inhales a medicine from a dry powder inhaler (DPI). Powder release from capsules has been shown to be influenced by the ILC. The characteristics used to measure this are the emitted dose, fine particle fraction and mass median aerodynamic diameter. In addition the ILC level is critical for capsule shell manufacture because it is an essential part of the process that cannot work without it. An experiment has been applied to the manufacture of inhalation capsules with the required ILC. A full factorial model was used to identify the controlling factors and from this a linear model has been proposed to improve control of the process. (C) 2016 Elsevier B.V. All rights reserved. | es_ES |
dc.description.sponsorship | This research was supported by Qualicaps Europe, S.A.U.; Spanish DGI Grant no. MTM2014-58159-P (M.T. Gasso) and G. Ayala (DPI2013-47279-C2-1-R), | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | International Journal of Pharmaceutics | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | HPMC capsules | es_ES |
dc.subject | Internal lubricant | es_ES |
dc.subject | Aerosolization | es_ES |
dc.subject | Dry powder inhaler (DPI) | es_ES |
dc.subject | Linear models | es_ES |
dc.subject.classification | MATEMATICA APLICADA | es_ES |
dc.title | Statistical tools and control of internal lubricant content of inhalation grade HPMC capsules during manufacture | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.ijpharm.2016.02.017 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//DPI2013-47279-C2-1-R/ES/HERRAMIENTAS PARA LA PREDICCION DE LA TALLA Y EL AJUSTE DE ROPA INFANTIL A PARTIR DE LA RECONSTRUCCION 3D DEL CUERPO Y DE TECNICAS BIG DATA/ / | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//MTM2014-58159-P/ES/PRECONDICIONADORES PARA SISTEMAS DE ECUACIONES LINEALES, PROBLEMAS DE MINIMOS CUADRADOS, CALCULO DE VALORES PROPIOS Y APLICACIONES TECNOLOGICAS/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escola Tècnica Superior d'Enginyeria Informàtica | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario de Matemática Multidisciplinar - Institut Universitari de Matemàtica Multidisciplinària | es_ES |
dc.description.bibliographicCitation | Ayala, G.; Diez, F.; Gasso Matoses, MT.; Jones, BE.; Martin-Portugues, R.; Ramiro-Aparicio, J. (2016). Statistical tools and control of internal lubricant content of inhalation grade HPMC capsules during manufacture. International Journal of Pharmaceutics. 503(1-2):36-40. doi:10.1016/j.ijpharm.2016.02.017 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.ijpharm.2016.02.017 | es_ES |
dc.description.upvformatpinicio | 36 | es_ES |
dc.description.upvformatpfin | 40 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 503 | es_ES |
dc.description.issue | 1-2 | es_ES |
dc.relation.senia | 316766 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |