- -

Influence of the spacer on the photoreactivity of flurbiprofen-tyrosine dyads

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

Influence of the spacer on the photoreactivity of flurbiprofen-tyrosine dyads

Show simple item record

Files in this item

dc.contributor.author Vayá Pérez, Ignacio es_ES
dc.contributor.author Gustavsson, Thomas es_ES
dc.contributor.author Markovitsi, Dimitra es_ES
dc.contributor.author Miranda Alonso, Miguel Ángel es_ES
dc.contributor.author Jiménez Molero, María Consuelo es_ES
dc.date.accessioned 2017-05-26T11:59:15Z
dc.date.available 2017-05-26T11:59:15Z
dc.date.issued 2016-05-15
dc.identifier.issn 1010-6030
dc.identifier.uri http://hdl.handle.net/10251/81835
dc.description.abstract [EN] The photoreactivity of diastereomeric dyads containing (S)- or (R)-flurbiprofen (FBP) and (S)-Tyr, either directly linked (1) or separated by a cyclic spacer (3) has been investigated. The main feature is a remarkable intramolecular quenching of FBP fluorescence, especially in 1. The process is clearly configuration dependent, being more efficient for the (R,S)- diastereomer in 1 and for the (S,S)-analogue in 3. Noteworthy, exciplex emission is detected in the 380-500 nm region in the case of 3. Fluorescence decay kinetics from the femtosecond to the nanosecond time-domains provides evidence for the dynamic nature of the quenching. In agreement with the steady-state and time-resolved observations, molecular modelling points to a more favourable geometric arrangement of the two interacting chromophores in 1 than in 3. es_ES
dc.description.sponsorship Financial support from the Spanish Government (CTQ2013-47872-C2-1-P), EU (PCIG12GA-2012-334257, LASERLAB-EUROPE grant agreement no. 284464, EU FP7, and MSCA- 657465) and Generalitat Valenciana (PROMETEOII/2013/005) is gratefully acknowledged. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation MICINN/CTQ2013-47872-C2-1-P es_ES
dc.relation GV/PROMETEOII/2013/005 es_ES
dc.relation.ispartof Journal of Photochemistry and Photobiology A: Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Exciplex es_ES
dc.subject Fluorescence quenching es_ES
dc.subject Fluorescence upconversion es_ES
dc.subject Laser flash photolysis es_ES
dc.subject Time-correlated single photon counting es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Influence of the spacer on the photoreactivity of flurbiprofen-tyrosine dyads es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.jphotochem.2016.03.006
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/284464/EU es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/657465/EU
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/334257/EU
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.description.bibliographicCitation Vayá Pérez, I.; Gustavsson, T.; Markovitsi, D.; Miranda Alonso, MÁ.; Jiménez Molero, MC. (2016). Influence of the spacer on the photoreactivity of flurbiprofen-tyrosine dyads. Journal of Photochemistry and Photobiology A: Chemistry. 322:95-101. doi:10.1016/j.jphotochem.2016.03.006 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://doi.org/10.1016/j.jphotochem.2016.03.006 es_ES
dc.description.upvformatpinicio 95 es_ES
dc.description.upvformatpfin 101 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 322 es_ES
dc.relation.senia 304708 es_ES
dc.contributor.funder European Commission
dc.contributor.funder Ministerio de Ciencia e Innovación (MICINN)
dc.contributor.funder Generalitat Valenciana (GV)


This item appears in the following Collection(s)

Show simple item record