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dc.contributor.author | Vayá Pérez, Ignacio![]() |
es_ES |
dc.contributor.author | Gustavsson, Thomas![]() |
es_ES |
dc.contributor.author | Markovitsi, Dimitra![]() |
es_ES |
dc.contributor.author | Miranda Alonso, Miguel Ángel![]() |
es_ES |
dc.contributor.author | Jiménez Molero, María Consuelo![]() |
es_ES |
dc.date.accessioned | 2017-05-26T11:59:15Z | |
dc.date.available | 2017-05-26T11:59:15Z | |
dc.date.issued | 2016-05-15 | |
dc.identifier.issn | 1010-6030 | |
dc.identifier.uri | http://hdl.handle.net/10251/81835 | |
dc.description.abstract | [EN] The photoreactivity of diastereomeric dyads containing (S)- or (R)-flurbiprofen (FBP) and (S)-Tyr, either directly linked (1) or separated by a cyclic spacer (3) has been investigated. The main feature is a remarkable intramolecular quenching of FBP fluorescence, especially in 1. The process is clearly configuration dependent, being more efficient for the (R,S)- diastereomer in 1 and for the (S,S)-analogue in 3. Noteworthy, exciplex emission is detected in the 380-500 nm region in the case of 3. Fluorescence decay kinetics from the femtosecond to the nanosecond time-domains provides evidence for the dynamic nature of the quenching. In agreement with the steady-state and time-resolved observations, molecular modelling points to a more favourable geometric arrangement of the two interacting chromophores in 1 than in 3. | es_ES |
dc.description.sponsorship | Financial support from the Spanish Government (CTQ2013-47872-C2-1-P), EU (PCIG12GA-2012-334257, LASERLAB-EUROPE grant agreement no. 284464, EU FP7, and MSCA- 657465) and Generalitat Valenciana (PROMETEOII/2013/005) is gratefully acknowledged. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Journal of Photochemistry and Photobiology A: Chemistry | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Exciplex | es_ES |
dc.subject | Fluorescence quenching | es_ES |
dc.subject | Fluorescence upconversion | es_ES |
dc.subject | Laser flash photolysis | es_ES |
dc.subject | Time-correlated single photon counting | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.subject.classification | QUIMICA ANALITICA | es_ES |
dc.title | Influence of the spacer on the photoreactivity of flurbiprofen-tyrosine dyads | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.jphotochem.2016.03.006 | |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/284464/EU/The Integrated Initiative of European Laser Research Infrastructures III/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//CTQ2013-47872-C2-1-P/ES/METABOLITOS FOTOACTIVOS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2013%2F005/ES/ESPECIES FOTOACTIVAS Y SU INTERACCION CON BIOMOLECULAS/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/657465/EU/Functionalized AuNPs and their use for biological applications/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/334257/EU/EXCITED STATES AS PROBES TO INVESTIGATE DRUG-DNA AND DRUG-PROTEIN INTERACTIONS. PHOTOSENSITIZED PROCESSES LEADING TO DAMAGE TO BIOMOLECULES/ | |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.description.bibliographicCitation | Vayá Pérez, I.; Gustavsson, T.; Markovitsi, D.; Miranda Alonso, MÁ.; Jiménez Molero, MC. (2016). Influence of the spacer on the photoreactivity of flurbiprofen-tyrosine dyads. Journal of Photochemistry and Photobiology A: Chemistry. 322:95-101. https://doi.org/10.1016/j.jphotochem.2016.03.006 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://doi.org/10.1016/j.jphotochem.2016.03.006 | es_ES |
dc.description.upvformatpinicio | 95 | es_ES |
dc.description.upvformatpfin | 101 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 322 | es_ES |
dc.relation.senia | 304708 | es_ES |
dc.contributor.funder | European Commission | |
dc.contributor.funder | Ministerio de Ciencia e Innovación | |
dc.contributor.funder | Generalitat Valenciana |