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Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs

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Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs

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dc.contributor.author Santiago Cuéllar, Julia es_ES
dc.contributor.author Dupeux, Florine es_ES
dc.contributor.author Betz, Katja es_ES
dc.contributor.author Antoni-Alandes, Regina es_ES
dc.contributor.author González Guzmán, Miguel es_ES
dc.contributor.author Rodriguez, Lesia es_ES
dc.contributor.author Márquez, José Antonio es_ES
dc.contributor.author Rodríguez Egea, Pedro Luís es_ES
dc.date.accessioned 2017-06-07T09:03:55Z
dc.date.available 2017-06-07T09:03:55Z
dc.date.issued 2012-01
dc.identifier.issn 0168-9452
dc.identifier.uri http://hdl.handle.net/10251/82498
dc.description.abstract [EN] Abscisic acid (ABA) plays an essential function in plant physiology since it is required for biotic and abiotic stress responses as well as control of plant growth and development. A new family of soluble ABA receptors, named PYR/PYL/RCAR, has emerged as ABA sensors able to inhibit the activity of specific protein phosphatases type-2C (PP2Cs) in an ABA-dependent manner. The structural and functional mechanism by which ABA is perceived by these receptors and consequently leads to inhibition of the PP2Cs has been recently elucidated. The module PYR/PYL/RCAR-ABA-PP2C offers an elegant and unprecedented mechanism to control phosphorylation signaling cascades in a ligand-dependent manner. The knowledge of their three-dimensional structures paves the way to the design of ABA agonists able to modulate the plant stress response. (C) 2010 Elsevier Ireland Ltd. All rights reserved. es_ES
dc.description.sponsorship We are grateful to the European Synchrotron Radiation Facility (ESRF) and the EMBL for access to macromolecular crystallography beam lines. Work in the laboratory of Dr Rodriguez is supported by grant BIO2008-00221 from Ministerio de Educación y Ciencia and Fondo Europeo de Desarrollo Regional and Consejo Superior de Investigaciones Científicas (fellowships to JS, RA and LR; Juan de la Cierva contract to MGG). Access to the high Throughput Crystallization facility of the Partnership for Structural Biology in Grenoble (PSB) (https://htxlab.embl.fr) was supported by the European Community – Research InfrastructureAction PCUBE under the FP7 “Capacities” specific program.
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation MEC/BIO2008-00221
dc.relation.ispartof Plant Science es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Phytohormone es_ES
dc.subject Abscisic acid es_ES
dc.subject Signaling/phosphatase-2C es_ES
dc.subject Receptor es_ES
dc.subject.classification MICROBIOLOGIA es_ES
dc.subject.classification BIOQUIMICA Y BIOLOGIA MOLECULAR es_ES
dc.title Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.plantsci.2010.11.014
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/227764/EU es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Biotecnología - Departament de Biotecnologia es_ES
dc.description.bibliographicCitation Santiago Cuéllar, J.; Dupeux, F.; Betz, K.; Antoni-Alandes, R.; González Guzmán, M.; Rodriguez, L.; Márquez, JA.... (2012). Structural insights into PYR/PYL/RCAR ABA receptors and PP2Cs. Plant Science. 182:3-11. https://doi.org/10.1016/j.plantsci.2010.11.014 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1016/j.plantsci.2010.11.014 es_ES
dc.description.upvformatpinicio 3 es_ES
dc.description.upvformatpfin 11 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 182 es_ES
dc.relation.senia 233158 es_ES
dc.identifier.pmid 22118610
dc.contributor.funder Ministerio de Educación y Ciencia
dc.contributor.funder European Commission
dc.contributor.funder Consejo Superior de Investigaciones Científicas


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