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Analytical methods for anti-doping control in sport: anabolic steroids with 4,9,11-triene structure in urine

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Analytical methods for anti-doping control in sport: anabolic steroids with 4,9,11-triene structure in urine

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dc.contributor.author Brun, Eva M. es_ES
dc.contributor.author Puchades, Rosa es_ES
dc.contributor.author Maquieira Catala, Ángel es_ES
dc.date.accessioned 2017-06-15T11:32:42Z
dc.date.available 2017-06-15T11:32:42Z
dc.date.issued 2011-05
dc.identifier.issn 0165-9936
dc.identifier.uri http://hdl.handle.net/10251/82888
dc.description.abstract [EN] Doping control in sport is mandatory to detect and to control the use of prohibited substances. Due to the growing number of targets, the analysis of doping compounds and their metabolites is carried out using established screening methods. However, detection of anabolic steroids with 4,9,11-triene structure in urine is problematic, so it is necessary to improve the methods. We review the state of the art in doping-control analysis of 4,9,11-trien-3-one steroids, providing an overview of the screening and confirmatory methods developed for these analytes in human urine. First, we review chromatographic techniques. We discuss difficulties in the derivatization of those compounds prior to gas chromatography analyses. In recent years, liquid chromatography has been the preferred technique in drug testing in sport, due to the reduced sample pre-treatment, improved limits of detection and comprehensiveness. We also report on advances and limitations of immunochemical techniques for the analysis of this group of substances. (C) 2011 Elsevier Ltd. All rights reserved. es_ES
dc.description.sponsorship This work is financed by Project DEP2006-56177-C03-03 (Spanish Ministerio de Ciencia e Innovacion). We thank Jorge Segura, Head of the Doping Control Laboratory Barcelona (Bioanalysis Research Group, IMIM-Hospital del Mar, Barcelona, Spain) for his valuable assistance in correcting the manuscript. We also thank the financial support of the Prometeo program from the Generalitat Valenciana.
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation MICINN/DEP2006-56177-C03-03 es_ES
dc.relation.ispartof Trends in Analytical Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject 4,9,11-triene structure es_ES
dc.subject Anabolic steroid es_ES
dc.subject Confirmatory method es_ES
dc.subject Derivatization es_ES
dc.subject Doping control es_ES
dc.subject Gas chromatography es_ES
dc.subject Immunochemical technique es_ES
dc.subject Liquid chromatography es_ES
dc.subject Metabolite es_ES
dc.subject Screening method es_ES
dc.subject Derivatizations es_ES
dc.subject Immunochemical techniques es_ES
dc.subject Biomolecules es_ES
dc.subject Body fluids es_ES
dc.subject Lipids es_ES
dc.subject Liquids es_ES
dc.subject Metabolism es_ES
dc.subject Metabolites es_ES
dc.subject 17 ketotrenbolone es_ES
dc.subject 17alpha trenbolone es_ES
dc.subject Altrenogest es_ES
dc.subject Anabolic agent es_ES
dc.subject Ethyltrenbolone es_ES
dc.subject Gastrinone es_ES
dc.subject Metribolone es_ES
dc.subject Propyltrenbolone es_ES
dc.subject Tetrahydrogestrinone es_ES
dc.subject Trenbolone es_ES
dc.subject Unclassified drug es_ES
dc.subject Analytic method es_ES
dc.subject Chromatography es_ES
dc.subject Drug screening es_ES
dc.subject Drug structure es_ES
dc.subject High performance liquid chromatography es_ES
dc.subject Human es_ES
dc.subject Immunochemistry es_ES
dc.subject Mass spectrometry es_ES
dc.subject Priority journal es_ES
dc.subject Review es_ES
dc.subject Sample es_ES
dc.subject Screening es_ES
dc.subject Sport es_ES
dc.subject Sports and sport related phenomena es_ES
dc.subject Urine level es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Analytical methods for anti-doping control in sport: anabolic steroids with 4,9,11-triene structure in urine es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.trac.2011.01.010
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Brun, EM.; Puchades, R.; Maquieira Catala, Á. (2011). Analytical methods for anti-doping control in sport: anabolic steroids with 4,9,11-triene structure in urine. Trends in Analytical Chemistry. 30(5):771-783. doi:10.1016/j.trac.2011.01.010 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://doi.org/10.1016/j.trac.2011.01.010 es_ES
dc.description.upvformatpinicio 771 es_ES
dc.description.upvformatpfin 783 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 30 es_ES
dc.description.issue 5 es_ES
dc.relation.senia 212754 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación


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