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dc.contributor.author | Elena Fito, Santiago Fco | es_ES |
dc.contributor.author | Lalic, Jasna | es_ES |
dc.date.accessioned | 2017-06-21T07:08:55Z | |
dc.date.available | 2017-06-21T07:08:55Z | |
dc.date.issued | 2013-12 | |
dc.identifier.issn | 0032-0862 | |
dc.identifier.uri | http://hdl.handle.net/10251/83306 | |
dc.description.abstract | [EN] Forecasting plant virus emergence depends on identifying the factors that determine the distribution of genetic variants within the primary host as well as across potential new hosts. It is crucial to determine: (i) the distribution of mutational fitness effects (DMFE) on the primary host, (ii) how it changes on different hosts, (iii) the way in which multiple mutations interact in determining viral fitness in the primary host, and (iv) whether this interaction is host-dependent. To illustrate points (i) and (ii), this paper reviews recent reports showing that the DMFE for a potyvirus markedly differs between natural and non-natural hosts. Changes in genetic variance for fitness are the main cause of the observed pattern among related hosts, whereas sign pleiotropy mainly explains differences observed among unrelated hosts. To illustrate point (iii), comments are made on experiments showing significant epistasis among random pairs of mutations in the potyvirus genome. A large fraction of the interactions correspond to the reciprocal sign epistasis, meaning that the sign of the effects of mutations at two loci are mutually dependent. Finally, to illustrate point (iv), evidence is presented that epistatic interactions for an RNA virus varied among hosts, with magnitude epistasis being stronger in the primary host but becoming weaker as host's taxonomic relatedness decreased. The existence of all these interactions jeopardizes the prediction of the fitness and evolutionary fate of a given mutation, as it will depend on the genetic background but also on the host wherein the virus replicates. | es_ES |
dc.description.sponsorship | The authors thank Stephanie Bedhomme, Jose M. Cuevas and Susanna K. Remold for insightful discussions and suggestions. This work was supported by grants BFU2009-06993 and BFU2012-30805 from Spanish Direccion General de Investigacion Cientifica y Tecnica to SFE. JL was supported by a JAE-pre contract from CSIC. | |
dc.language | Inglés | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation.ispartof | Plant Pathology | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Emerging viruses | es_ES |
dc.subject | Epistasis | es_ES |
dc.subject | Mutational effects | es_ES |
dc.subject | Pleiotropy | es_ES |
dc.subject | Reaction norms | es_ES |
dc.subject | Virus evolution | es_ES |
dc.title | Plant RNA virus fitness predictability: contribution of genetic and environmental factors | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1111/ppa.12102 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BFU2009-06993/ES/Biologia Evolutiva Y De Sistemas De La Emergencia De Fitovirus De Rna/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//BFU2012-30805/ES/EVOLUTIONARY SYSTEMS VIROLOGY: EPISTASIS AND THE RUGGEDNESS OF ADAPTIVE LANDSCAPES, MUTATIONS IN REGULATORY SEQUENCES, AND THE HOST DETERMINANTS OF VIRAL FITNESS/ | |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes | es_ES |
dc.description.bibliographicCitation | Elena Fito, SF.; Lalic, J. (2013). Plant RNA virus fitness predictability: contribution of genetic and environmental factors. Plant Pathology. 62(10-18):10-18. https://doi.org/10.1111/ppa.12102 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://doi.org/10.1111/ppa.12102 | es_ES |
dc.description.upvformatpinicio | 10 | es_ES |
dc.description.upvformatpfin | 18 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 62 | es_ES |
dc.description.issue | 10-18 | es_ES |
dc.relation.senia | 260572 | es_ES |
dc.identifier.eissn | 1365-3059 | |
dc.contributor.funder | Ministerio de Economía y Competitividad |