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dc.contributor.author | Climent Olmedo, María José | es_ES |
dc.contributor.author | Corma Canós, Avelino | es_ES |
dc.contributor.author | Iborra Chornet, Sara | es_ES |
dc.contributor.author | Martí Montaner, Laura | es_ES |
dc.date.accessioned | 2017-06-22T10:05:06Z | |
dc.date.available | 2017-06-22T10:05:06Z | |
dc.date.issued | 2016-04-06 | |
dc.identifier.issn | 1867-3880 | |
dc.identifier.uri | http://hdl.handle.net/10251/83435 | |
dc.description.abstract | Solid catalysts can be an alternative to homogeneous mineral Bronsted and Lewis acids for the synthesis of pharmaceuticals provided that diffusional and adsorption properties of reactants and products could be controlled. Structured micro and especially monolayered zeolites and mesoporous material can be active and selective for performing intramolecular cyclization reaction, and more specifically for intramolecular aza-Michael cyclizations of 2¿-aminochalcones to yield aryl-2,3-dihydro-4(1H)-quinolinones of pharmaceutical interest. However, the catalyst deactivates by strong adsorption of the basic quinolinone product. Product desorption has been controlled by optimizing catalyst pore structure and surface composition, together with a proper selection of solvent and reaction temperature. Process intensification for the synthesis of aryl-2,3-4(1H)-quinolinones of pharmaceutical interest has been achieved by preparing catalysts that allow the one pot synthesis of the dihydroquinolinones starting from 2 -nitrochalcones with excellent yields. | es_ES |
dc.description.sponsorship | Financial support from Consolider-Ingenio 2010 (project MULTI-CAT), Spanish MICINN Project (CTQ-2011-27550), Generalitat Valenciana (Prometeo program), and Program Severo Ochoa are gratefully acknowledged. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation.ispartof | ChemCatChem | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | 2-aminochalcones | es_ES |
dc.subject | Dihydroquinolinones | es_ES |
dc.subject | Fine chemicals | es_ES |
dc.subject | ITQ-2 zeolite | es_ES |
dc.subject | MCM-41 | es_ES |
dc.subject | One-pot process | es_ES |
dc.subject.classification | QUIMICA ORGANICA | es_ES |
dc.title | Use of mesoporous molecular sieves in the production of fine chemicals: Preparation of dihydroquinolinones of pharmaceutical interest from 2’-aminochalcones | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1002/cctc.201501403 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//CSD2009-00050/ES/Desarrollo de catalizadores más eficientes para el diseño de procesos químicos sostenibles y produccion limpia de energia/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//SEV2012-0267/ES/ | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//CTQ2011-27550/ES/TRANSFORMACION CATALITICA DE BIOMASA EN DIESEL Y EN PRODUCTOS QUIMICOS/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Química - Departament de Química | es_ES |
dc.description.bibliographicCitation | Climent Olmedo, MJ.; Corma Canós, A.; Iborra Chornet, S.; Martí Montaner, L. (2016). Use of mesoporous molecular sieves in the production of fine chemicals: Preparation of dihydroquinolinones of pharmaceutical interest from 2’-aminochalcones. ChemCatChem. 8(7):1335-1345. https://doi.org/10.1002/cctc.201501403 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://doi.org/10.1002/cctc.201501403 | es_ES |
dc.description.upvformatpinicio | 1335 | es_ES |
dc.description.upvformatpfin | 1345 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 8 | es_ES |
dc.description.issue | 7 | es_ES |
dc.relation.senia | 334743 | es_ES |
dc.identifier.eissn | 1867-3899 | |
dc.contributor.funder | Ministerio de Ciencia e Innovación | es_ES |
dc.contributor.funder | Generalitat Valenciana | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad |