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Genetic redundancies enhance information transfer in noisy regulatory circuits

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Genetic redundancies enhance information transfer in noisy regulatory circuits

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dc.contributor.author Rodrigo Tarrega, Guillermo es_ES
dc.contributor.author Poyatos, Juan F. es_ES
dc.date.accessioned 2017-06-27T12:36:04Z
dc.date.available 2017-06-27T12:36:04Z
dc.date.issued 2016-10
dc.identifier.issn 1553-734X
dc.identifier.uri http://hdl.handle.net/10251/83827
dc.description.abstract [EN] Cellular decision making is based on regulatory circuits that associate signal thresholds to specific physiological actions. This transmission of information is subjected to molecular noise what can decrease its fidelity. Here, we show instead how such intrinsic noise enhances information transfer in the presence of multiple circuit copies. The result is due to the contribution of noise to the generation of autonomous responses by each copy, which are altogether associated with a common decision. Moreover, factors that correlate the responses of the redundant units (extrinsic noise or regulatory cross-talk) contribute to reduce fidelity, while those that further uncouple them (heterogeneity within the copies) can lead to stronger information gain. Overall, our study emphasizes how the interplay of signal thresholding, redundancy, and noise influences the accuracy of cellular decision making. Understanding this interplay provides a basis to explain collective cell signaling mechanisms, and to engineer robust decisions with noisy genetic circuits.
dc.description.sponsorship This work has been supported by BFU2015-66894-P (MINECO/FEDER) and GV/2016/079 (GVA) Grants. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.language Inglés es_ES
dc.publisher Public Library of Science es_ES
dc.relation.ispartof PLoS Computational Biology es_ES
dc.rights Reconocimiento (by) es_ES
dc.subject Biochemical signaling networks es_ES
dc.subject Stochastic resonance es_ES
dc.subject Transcriptional regulation es_ES
dc.subject Decision-making es_ES
dc.subject Expression es_ES
dc.subject Transmission es_ES
dc.subject Cell es_ES
dc.subject Heterogeneity es_ES
dc.subject Variability es_ES
dc.subject Robustness es_ES
dc.title Genetic redundancies enhance information transfer in noisy regulatory circuits es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1371/journal.pcbi.1005156
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//BFU2015-66894-P /ES/MODELADO, DISEÑO DE NOVO E INGENIERIA DE INTERRUPTORES DE RNA QUE RESPONDEN A SEÑALES GENETICAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//GV%2F2016%2F079/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario Mixto de Biología Molecular y Celular de Plantas - Institut Universitari Mixt de Biologia Molecular i Cel·lular de Plantes es_ES
dc.description.bibliographicCitation Rodrigo Tarrega, G.; Poyatos, JF. (2016). Genetic redundancies enhance information transfer in noisy regulatory circuits. PLoS Computational Biology. 12(10). https://doi.org/10.1371/journal.pcbi.1005156 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1371/journal.pcbi.1005156 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 12 es_ES
dc.description.issue 10 es_ES
dc.relation.senia 331856 es_ES
dc.identifier.eissn 1553-7358
dc.identifier.pmid 27741249 en_EN
dc.identifier.pmcid PMC5065233
dc.contributor.funder Ministerio de Economía y Competitividad
dc.contributor.funder Generalitat Valenciana


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