- -

High efficiency amplified spontaneous emission from a fluorescent anticancer drug-dye complex

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

High efficiency amplified spontaneous emission from a fluorescent anticancer drug-dye complex

Show simple item record

Files in this item

dc.contributor.author Lahoz, Fernando es_ES
dc.contributor.author Oton Nieto, Claudio José es_ES
dc.contributor.author López, David es_ES
dc.contributor.author Marrero-Alonso, Jorge es_ES
dc.contributor.author Boto, Alicia es_ES
dc.contributor.author Diaz González, Mario es_ES
dc.date.accessioned 2017-07-03T07:28:17Z
dc.date.available 2017-07-03T07:28:17Z
dc.date.issued 2013-05
dc.identifier.issn 1566-1199
dc.identifier.uri http://hdl.handle.net/10251/84290
dc.description.abstract [EN] External amplified spontaneous emission (ASE) efficiency around 30% is reported for an optically active molecule, which at the same time shows antitumor activity. The complex is formed by the covalent binding of an anticancer drug, tamoxifen, commonly applied in breast cancer therapy, and nitro-2-1,3-benzoxadiazol-4-yl (NBD) dye, which is frequently used as a biomarker in hydrophobic environments, such as lipid membranes. A laser-like pump threshold around 100 kW/cm(2) was found in solutions of the fluorescent drug diluted in acetone or in oil. Agreement with an ASE spatial propagation model, as well as the lack of optical feedback in the walls of the dilution cuvette confirms that ASE is the physical mechanism that explains the high efficiency observed. The waveguide character and the polarization dependence of ASE are also studied. Highly efficient optical gain in such systems suggests new biophotonic applications. (C) 2013 Elsevier B. V. All rights reserved. es_ES
dc.description.sponsorship This study has been supported by research grants from Agencia Canaria de Investigacion, Innovacion y Sociedad de la Informacion, Gobierno de Canarias, through Project Sol-SubC200801000088 and Ministerio de Economia y Competividad Grant Numbers SAF2010-22114-C02-01 and CTQ2009-07109. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation.ispartof Organic Electronics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Amplified spontaneous emission es_ES
dc.subject Fluorescent drugs es_ES
dc.subject Dye es_ES
dc.subject Tamoxifen es_ES
dc.subject Biophotonics es_ES
dc.title High efficiency amplified spontaneous emission from a fluorescent anticancer drug-dye complex es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.orgel.2013.02.015
dc.relation.projectID info:eu-repo/grantAgreement/ACIISI//Sol-SubC200801000088/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//SAF2010-22114-C02-01/ES/ANALISIS LIPIDOMICO DE LIPID RAFTS DE CORTEX CEREBRAL EN ENFERMEDADES NEURODEGENERATIVAS/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//CTQ2009-07109/ES// es_ES
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto Universitario de Tecnología Nanofotónica - Institut Universitari de Tecnologia Nanofotònica es_ES
dc.description.bibliographicCitation Lahoz, F.; Oton Nieto, CJ.; López, D.; Marrero-Alonso, J.; Boto, A.; Diaz González, M. (2013). High efficiency amplified spontaneous emission from a fluorescent anticancer drug-dye complex. Organic Electronics. 14(5):1225-1230. https://doi.org/10.1016/j.orgel.2013.02.015 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1016/j.orgel.2013.02.015 es_ES
dc.description.upvformatpinicio 1225 es_ES
dc.description.upvformatpfin 1230 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 14 es_ES
dc.description.issue 5 es_ES
dc.relation.senia 250515 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Agencia Canaria de Investigación, Innovación y Sociedad de la Información es_ES


This item appears in the following Collection(s)

Show simple item record