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Enhanced photo(geno)toxicity of demethylated chlorpromazine metabolites

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Enhanced photo(geno)toxicity of demethylated chlorpromazine metabolites

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Palumbo, F.; García Lainez, G.; Limones Herrero, D.; Coloma, MD.; Escobar, J.; Jiménez Molero, MC.; Miranda Alonso, MÁ.... (2016). Enhanced photo(geno)toxicity of demethylated chlorpromazine metabolites. Toxicology and Applied Pharmacology. 313:231-237. doi:10.1016/j.taap.2016.10.024

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Title: Enhanced photo(geno)toxicity of demethylated chlorpromazine metabolites
Author:
UPV Unit: Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Universitat Politècnica de València. Departamento de Química - Departament de Química
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Abstract:
Chlorpromazine (CPZ) is an anti-psychotic drug widely used to treat disorders such as schizophrenia or manic-depression. Unfortunately, CPZ exhibits undesirable side effects such as phototoxic and photoallergic reactions ...[+]
Subjects: Comet assay , Excited states , Laser flash photolysis , Metabolites , Photosensitized DNA damage , Phototoxicity
Copyrigths: Reserva de todos los derechos
Source:
Toxicology and Applied Pharmacology. (issn: 0041-008X ) (eissn: 1096-0333 )
DOI: 10.1016/j.taap.2016.10.024
Publisher:
Elsevier
Publisher version: http://doi.org/10.1016/j.taap.2016.10.024
Thanks:
This work was supported by the MINECO (Grant: CTQ2013-47872), by Carlos III Institute of Health (Grants: RD12/0013/0009 and CP11/00154) and by the Generalitat Valenciana (Prometeo II/2013/005).
Type: Artículo

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