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dc.contributor.author | Chen, S.J. | es_ES |
dc.contributor.author | Liu, Y.J. | es_ES |
dc.contributor.author | Liu, T. | es_ES |
dc.contributor.author | Chen, B.J. | es_ES |
dc.contributor.author | Gu, Z.L. | es_ES |
dc.date.accessioned | 2017-07-10T10:01:11Z | |
dc.date.available | 2017-07-10T10:01:11Z | |
dc.date.issued | 2017-06-28 | |
dc.identifier.issn | 1257-5011 | |
dc.identifier.uri | http://hdl.handle.net/10251/84832 | |
dc.description.abstract | [EN] Wool density is an important index that influences Rex rabbit fur quality. In our earlier studies, we found some important differentially expressed genes in different wool density of Rex rabbit by cDNA microarray. Based on the outcome, we conducted an association study to identify single nucleotide polymorphisms (SNPs) of exon 1, 5, 7 and 10 of matrix metalloproteinase-2 (MMP2) gene and their ligands associated with wool density. The results showed that exon 1 and exon 10 of MMP2 gene did not occur mutation in 100 Rex rabbits, meanwhile 3 SNPs were identified in exon 5, exon 7 and intron 10 of MMP2 gene sequence respectively, the 3 mutation sites were as follows: MMP2-exon 5-26C/G, MMP2-exon 7-101C/T and MMP2-intron 10-6C/T. The 3 SNPs were all in Hardy-Weinberg equilibrium. Phenotypic correlation analysis results showed the 3 mutations lacked significant associations (P>0.05) with the wool density. | es_ES |
dc.description.sponsorship | This work was supported by Natural Science Foundation Projects from Hebei Province of P.R.China (#C2014204019) and the Science and Technology Research Projects in Colleges from Hebei Province of P.R.China (#bj2014035). | |
dc.language | Inglés | es_ES |
dc.publisher | Universitat Politècnica de València | |
dc.relation.ispartof | World Rabbit Science | |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Rex rabbit | es_ES |
dc.subject | MMP2 gene | es_ES |
dc.subject | SNPs | es_ES |
dc.subject | Fur | es_ES |
dc.subject | Wool density | es_ES |
dc.title | Polymorphisms of exon 5, exon 7 and intron 10 of MMP2 gene and their association with wool density in Rex rabbits | es_ES |
dc.type | Artículo | es_ES |
dc.date.updated | 2017-07-10T07:30:30Z | |
dc.identifier.doi | 10.4995/wrs.2017.6514 | |
dc.relation.projectID | info:eu-repo/grantAgreement/NSFC//#C2014204019/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/NSFC//#bj2014035/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.description.bibliographicCitation | Chen, S.; Liu, Y.; Liu, T.; Chen, B.; Gu, Z. (2017). Polymorphisms of exon 5, exon 7 and intron 10 of MMP2 gene and their association with wool density in Rex rabbits. World Rabbit Science. 25(2):181-184. https://doi.org/10.4995/wrs.2017.6514 | es_ES |
dc.description.accrualMethod | SWORD | es_ES |
dc.relation.publisherversion | https://doi.org/10.4995/wrs.2017.6514 | es_ES |
dc.description.upvformatpinicio | 181 | es_ES |
dc.description.upvformatpfin | 184 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 25 | |
dc.description.issue | 2 | |
dc.identifier.eissn | 1989-8886 | |
dc.contributor.funder | National Natural Science Foundation of China |