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Glutathione-sensitive nanoplatform for monitored intracellular delivery and controlled release of Camptothecin

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Glutathione-sensitive nanoplatform for monitored intracellular delivery and controlled release of Camptothecin

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Muniesa Lajara, C.; Vicente Vilas, V.; Quesada Vilar, M.; Saez-Atienzar, S.; Blesa-Blesa, JR.; Abasolo, I.; Fernández, Y.... (2013). Glutathione-sensitive nanoplatform for monitored intracellular delivery and controlled release of Camptothecin. RSC Advances. 3(35):15121-15131. https://doi.org/10.1039/c3ra41404c

Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10251/85514

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Title: Glutathione-sensitive nanoplatform for monitored intracellular delivery and controlled release of Camptothecin
Author: Muniesa Lajara, Carlos Vicente Vilas, Victor Quesada Vilar, Manuel SAEZ-ATIENZAR, SARA BLESA-BLESA, JOSE RAFAEL Abasolo, Ibane Fernández, Yolanda Botella Asuncion, Pablo
UPV Unit: Universitat Politècnica de València. Instituto Universitario Mixto de Tecnología Química - Institut Universitari Mixt de Tecnologia Química
Issued date:
Abstract:
[EN] We report the design, synthesis, characterization and in vitro testing of a novel nanodrug based on a covalent linking model that allows intracellular controlled release of the pharmaceutical payload. A new synthetic ...[+]
Subjects: Mesopourus silica nanoparticles , Drug delivery , Responsive nanoparticles , Carbon nanotubes , Disulfide bonds , Gene delivery , Cancer cells , In vivo , Agents , Folate
Copyrigths: Reconocimiento (by)
Source:
RSC Advances. (issn: 2046-2069 )
DOI: 10.1039/c3ra41404c
Publisher:
Royal Society of Chemistry
Publisher version: http://doi.org/10.1039/c3ra41404c
Project ID:
info:eu-repo/grantAgreement/MICINN//CSD2009-00050/ES/Desarrollo de catalizadores más eficientes para el diseño de procesos químicos sostenibles y produccion limpia de energia/
ISCIII/PI080771
UCV/PI2011-011-010
info:eu-repo/grantAgreement/MINECO//MAT2012-39290-C02-02/ES/NUEVAS CUBIERTAS BIOCOMPATIBLES Y ANTIINFLAMATORIAS PARA ELECTRODOS NEURALES/
Thanks:
This work was financially supported by "Comision Interministerial de Ciencia y Tecnologia" of Spain (projects CSD2009-00050 and MAT2012-39290-C02-02), and grants from CIBER-BBN (NanoMets Intramural Grant) "Fondo de ...[+]
Type: Artículo

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