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Mathematical modelling of Respiratory Syncytial Virus spread in the Spanish region of Valencia. Preventive applications

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Mathematical modelling of Respiratory Syncytial Virus spread in the Spanish region of Valencia. Preventive applications

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dc.contributor.advisor Jódar Sánchez, Lucas Antonio es_ES
dc.contributor.advisor Villanueva Micó, Rafael Jacinto es_ES
dc.contributor.author Moraño Fernández, José Antonio es_ES
dc.date.accessioned 2010-10-06T11:24:35Z
dc.date.available 2010-10-06T11:24:35Z
dc.date.created 2010-09-17T08:00:00Z es_ES
dc.date.issued 2010-10-06T11:24:33Z es_ES
dc.identifier.uri http://hdl.handle.net/10251/8638
dc.description.abstract This dissertation is related to mathematical modelling of the spread of respiratory syncytial virus (RSV) in Valencia and is still causing a large number of hospitalizations of children in this community. A mathematical model based on a system of nonlinear differential equations of first order has been built. This model considers the population divided into two age groups to pay particular attention to children under one year who are the most affected by this disease. This model has been fitted with hospitalizations data of Valencia and has been used to perform a cost analysis of a potential vaccination strategy. We also propose a complete network model to study the seasonal evolution of RSV epidemics in which seasonal parameters were fitted with the previous continuous model. Both developments are contrasted. On the complete network model we propose a strategy for vaccination of children based on the administration of three doses, and develop a cost-effectiveness study for different vaccination rates. Finally we have defined a SIRS model for RSV epidemics on a random social network of contacts among individuals. In this model has not forced the seasonality. The seasonality arises naturally for certain values of the duration of immunity of a patient recovered, the number of contacts and the likelihood of infection from a contact in a day. In this social network model only a narrow range of parameters can support RSV epidemic seasons. es_ES
dc.language Inglés es_ES
dc.rights Reserva de todos los derechos es_ES
dc.source Riunet
dc.subject Rsv es_ES
dc.subject Respiratory syncytial virus es_ES
dc.subject Random network model es_ES
dc.subject Simulation es_ES
dc.subject.classification MATEMATICA APLICADA es_ES
dc.title Mathematical modelling of Respiratory Syncytial Virus spread in the Spanish region of Valencia. Preventive applications
dc.type Tesis doctoral es_ES
dc.subject.unesco 120602 - Ecuaciones diferenciales es_ES
dc.subject.unesco 120326 - Simulación es_ES
dc.subject.unesco 520605 - Características epidemiológicas es_ES
dc.subject.unesco 242008 - Virus respiratorios es_ES
dc.identifier.doi 10.4995/Thesis/10251/8638 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Matemática Aplicada - Departament de Matemàtica Aplicada es_ES
dc.description.bibliographicCitation Moraño Fernández, JA. (2010). Mathematical modelling of Respiratory Syncytial Virus spread in the Spanish region of Valencia. Preventive applications [Tesis doctoral no publicada]. Universitat Politècnica de València. doi:10.4995/Thesis/10251/8638. es_ES
dc.type.version info:eu-repo/semantics/acceptedVersion es_ES
dc.relation.tesis 3373 es_ES


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