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Polyglutamic Acid-Gated Mesoporous Silica Nanoparticles for Enzyme-Controlled Drug Delivery

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Polyglutamic Acid-Gated Mesoporous Silica Nanoparticles for Enzyme-Controlled Drug Delivery

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dc.contributor.author Tukappa, Asha es_ES
dc.contributor.author Ultimo, Amelia es_ES
dc.contributor.author De la Torre Paredes, Cristina es_ES
dc.contributor.author Pardo Vicente, María Teresa es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2017-09-05T14:17:31Z
dc.date.issued 2016-08-23
dc.identifier.issn 0743-7463
dc.identifier.uri http://hdl.handle.net/10251/86458
dc.description This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.langmuir.6b01715. es_ES
dc.description.abstract Mesoporous silica nanoparticles (MSNs) are highly attractive as supports in the design of controlled delivery systems that can act as containers for the encapsulation of therapeutic agents, overcoming common issues such as poor water solubility and poor stability of some drugs and also enhancing their bioavailability. In this context, we describe herein the development of polyglutamic acid (PGA)-capped MSNs that can selectively deliver rhodamine B and doxorubicin. PGA-capped MSNs remain closed in an aqueous environment, yet they are able to deliver the cargo in the presence of pronase because of the hydrolysis of the peptide bonds in PGA. The prepared solids released less than 20% of the cargo in 1 day in water, whereas they were able to reach 90% of the maximum release of the entrapped guest in ca. 5 h in the presence of pronase. Studies of the PGA-capped nanoparticles with SK-BR-3 breast cancer cells were also undertaken. Rhodamine-loaded nanoparticles were not toxic, whereas doxorubicin-loaded nanoparticles were able to efficiently kill more than 90% of the cancer cells at a concentration of 100 μg/mL. es_ES
dc.description.sponsorship A.T. wishes to express her gratitude to the Erasmus mundus (Svagata.eu) financial support. A.U. and C. de la T. are grateful to the Spanish Ministry of Education, Culture and Sport for her doctoral fellowship. We thank the Spanish Government (Project MAT2015-64139-C4-1-R, MINECO/FEDER) and Generalitat Valenciana (Project PROMETEOII/2014/047) for their support. The authors also thank UPV electron microscopy services for the technical support. en_EN
dc.language Inglés es_ES
dc.publisher American Chemical Society es_ES
dc.relation.ispartof Langmuir es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Operated mechanized nanoparticles es_ES
dc.subject Metastatic breast-cancer es_ES
dc.subject Controlled-release es_ES
dc.subject Guest molecules es_ES
dc.subject Targeted delivery es_ES
dc.subject Soluble drugs es_ES
dc.subject DNA es_ES
dc.subject Systems es_ES
dc.subject Nanomedicine es_ES
dc.subject Supports es_ES
dc.subject Electron Microscopy Service of the UPV es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title Polyglutamic Acid-Gated Mesoporous Silica Nanoparticles for Enzyme-Controlled Drug Delivery es_ES
dc.type Artículo es_ES
dc.embargo.lift 10000-01-01
dc.embargo.terms forever es_ES
dc.identifier.doi 10.1021/acs.langmuir.6b01715
dc.relation.projectID info:eu-repo/grantAgreement/MINECO//MAT2015-64139-C4-1-R/ES/NANOMATERIALES INTELIGENTES, SONDAS Y DISPOSITIVOS PARA EL DESARROLLO INTEGRADO DE NUEVAS HERRAMIENTAS APLICADAS AL CAMPO BIOMEDICO/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/GVA//PROMETEOII%2F2014%2F047/ES/Nuevas aproximaciones para el diseño de materiales de liberación controlada y la detección de compuestos peligrosos/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Tukappa, A.; Ultimo, A.; De La Torre Paredes, C.; Pardo Vicente, MT.; Sancenón Galarza, F.; Martínez-Máñez, R. (2016). Polyglutamic Acid-Gated Mesoporous Silica Nanoparticles for Enzyme-Controlled Drug Delivery. Langmuir. 32(33):8507-8515. https://doi.org/10.1021/acs.langmuir.6b01715 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://dx.doi.org/10.1021/acs.langmuir.6b01715 es_ES
dc.description.upvformatpinicio 8507 es_ES
dc.description.upvformatpfin 8515 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 32 es_ES
dc.description.issue 33 es_ES
dc.relation.senia 318271 es_ES
dc.contributor.funder Ministerio de Economía y Competitividad es_ES
dc.contributor.funder European Commission es_ES
dc.contributor.funder Generalitat Valenciana es_ES
dc.contributor.funder Ministerio de Educación, Cultura y Deporte es_ES


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