- -

NIR hyperspectral imaging to evaluate degradation in captopril commercial tablets

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

NIR hyperspectral imaging to evaluate degradation in captopril commercial tablets

Show simple item record

Files in this item

dc.contributor.author Franca, Leandro de Moura es_ES
dc.contributor.author Pimentel, Maria Fernanda es_ES
dc.contributor.author Simoes, Simone da Silva es_ES
dc.contributor.author Grangeiro, Severino, Jr. es_ES
dc.contributor.author Prats-Montalbán, José Manuel es_ES
dc.contributor.author Ferrer, Alberto es_ES
dc.date.accessioned 2017-09-25T10:10:42Z
dc.date.available 2017-09-25T10:10:42Z
dc.date.issued 2016-07
dc.identifier.issn 0939-6411
dc.identifier.uri http://hdl.handle.net/10251/87903
dc.description.abstract [EN] Pharmaceutical quality control is important for improving the effectiveness, purity and safety of drugs, as well as for the prevention or control of drug degradation. In the present work, near infrared hyperspectral images (HSI-NIR) of tablets with different expiration dates were employed to evaluate the degradation of captopril into captopril disulfide in different layers, on the top and on the bottom surfaces of the tablets. Multivariate curve resolution (MCR) models were used to extract the concentration distribution maps from the hyperspectral images. Afterward, multivariate image techniques were applied to the concentration distribution maps (CDMs), to extract features and build models relating the main characteristics of the images to their corresponding manufacturing dates. Resolution methods followed by extracting features were able to estimate the tablet manufacture date with a prediction error of 120 days. The model developed could be useful to evaluate whether a sample shows a degradation pattern consistent with the date of manufacturing or to detect abnormal behaviors in the natural degradation process of the sample. The information provided by the HIS-NIR is important for the development of the process (QbD), looking inside the formulation, revealing the behavior of the active pharmaceutical ingredient (API) during the product's shelf life. es_ES
dc.description.sponsorship The authors thank the contribution of the agencies CNPq, FACEPE/NUQAAPE and Instituto Nacional de Ciencias e Tecnologias Analiticas Avancadas INCTAA (CNPq - proc. no. 573894/2008-6 and FAPESP proc. no. 2008/57808-1). The authors are also grateful to Prof. Jose Manuel Amigo for manuscript revision and suggestions. en_EN
dc.language Inglés es_ES
dc.publisher Elsevier es_ES
dc.relation FACEPE/NUQAAPE es_ES
dc.relation Instituto Nacional de Ciencias e Tecnologias Analiticas Avancadas INCTAA (CNPq) 573894/2008-6 es_ES
dc.relation Instituto Nacional de Ciencias e Tecnologias Analiticas Avancadas INCTAA (FAPESP) 2008/57808-1 es_ES
dc.relation.ispartof European Journal of Pharmaceutics and Biopharmaceutics es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Near infrared spectroscopy es_ES
dc.subject Imaging analysis es_ES
dc.subject Process analytical technology es_ES
dc.subject Degradation product es_ES
dc.subject Feature extraction es_ES
dc.subject.classification ESTADISTICA E INVESTIGACION OPERATIVA es_ES
dc.title NIR hyperspectral imaging to evaluate degradation in captopril commercial tablets es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1016/j.ejpb.2016.05.005
dc.rights.accessRights Cerrado es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.description.bibliographicCitation Franca, LDM.; Pimentel, MF.; Simoes, SDS.; Grangeiro, SJ.; Prats-Montalbán, JM.; Ferrer, A. (2016). NIR hyperspectral imaging to evaluate degradation in captopril commercial tablets. European Journal of Pharmaceutics and Biopharmaceutics. 104:180-188. doi:10.1016/j.ejpb.2016.05.005 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi. org/10.1016/j.ejpb.2016.05.005 es_ES
dc.description.upvformatpinicio 180 es_ES
dc.description.upvformatpfin 188 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 104 es_ES
dc.relation.senia 316992 es_ES
dc.identifier.eissn 1873-3441


This item appears in the following Collection(s)

Show simple item record