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Molecular gated nanoporous anodic alumina for the detection of cocaine

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Molecular gated nanoporous anodic alumina for the detection of cocaine

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dc.contributor.author Ribes, Àngela es_ES
dc.contributor.author Xifre Perez, Elisabet es_ES
dc.contributor.author Aznar, Elena es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Pardo Vicente, María Teresa es_ES
dc.contributor.author Marsal, Lluis F. es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.date.accessioned 2017-09-28T12:00:30Z
dc.date.available 2017-09-28T12:00:30Z
dc.date.issued 2016-12-07
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10251/88178
dc.description.abstract [EN] We present herein the use of nanoporous anodic alumina (NAA) as a suitable support to implement molecular gates for sensing applications. In our design, a NAA support is loaded with a fluorescent reporter (rhodamine B) and functionalized with a short single-stranded DNA. Then pores are blocked by the subsequent hybridisation of a specific cocaine aptamer. The response of the gated material was studied in aqueous solution. In a typical experiment, the support was immersed in hybridisation buffer solution in the absence or presence of cocaine. At certain times, the release of rhodamine B from pore voids was measured by fluorescence spectroscopy. The capped NAA support showed poor cargo delivery, but presence of cocaine in the solution selectively induced rhodamine B release. By this simple procedure a limit of detection as low as 5 × 10−7 M was calculated for cocaine. The gated NAA was successfully applied to detect cocaine in saliva samples and the possible re-use of the nanostructures was assessed. Based on these results, we believe that NAA could be a suitable support to prepare optical gated probes with a synergic combination of the favourable features of selected gated sensing systems and NAA. es_ES
dc.description.sponsorship We thank Projects MAT2015-64139-C4-1-R and TEC2015-71324-R (MINECO/FEDER), the Catalan Government (Project 2014 SGR 1344), the ICREA (ICREA2014 Academia Award) and the Generalitat Valenciana (Project PROMETEOII/2014/047) for support. We also thank to the Agencia Espanola del Medicamento y Productos Sanitarios for its concessions. A.R. thanks the UPV for her predoctoral fellowship. The authors also thank the Electron Microscopy Service at UPV for support. en_EN
dc.language Inglés es_ES
dc.publisher Nature Publishing Group es_ES
dc.relation MINECO/FEDER/MAT2015-64139-C4-1-R es_ES
dc.relation GC/2014 SGR 1344 es_ES
dc.relation GV/PROMETEOII/2014/047 es_ES
dc.relation MINECO/FEDER/TEC2015-71324-R es_ES
dc.relation.ispartof Scientific Reports es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject BIORESPONSIVE CONTROLLED-RELEASE es_ES
dc.subject MESOPOROUS SILICA NANOPARTICLES es_ES
dc.subject RESPONSIVE DRUG-DELIVERY es_ES
dc.subject APTAMER-BASED SENSOR es_ES
dc.subject ORAL FLUID es_ES
dc.subject DNA es_ES
dc.subject SYSTEMS es_ES
dc.subject PLATFORM es_ES
dc.subject SPECIFICITY es_ES
dc.subject APTASENSOR es_ES
dc.subject Electron Microscopy Service of the UPV
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Molecular gated nanoporous anodic alumina for the detection of cocaine es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1038/srep38649
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Centro de Tecnologías Físicas: Acústica, Materiales y Astrofísica - Centre de Tecnologies Físiques: Acústica, Materials i Astrofísica es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería del Diseño - Escola Tècnica Superior d'Enginyeria del Disseny es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.description.bibliographicCitation Ribes, À.; Xifre Perez, E.; Aznar, E.; Sancenón Galarza, F.; Pardo Vicente, MT.; Marsal, LF.; Martínez-Máñez, R. (2016). Molecular gated nanoporous anodic alumina for the detection of cocaine. Scientific Reports. 6. doi:10.1038/srep38649 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://doi.org/10.1038/srep38649 es_ES
dc.description.upvformatpinicio 38649 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 6 es_ES
dc.relation.senia 322618 es_ES
dc.identifier.pmid 27924950
dc.identifier.pmcid PMC5141502 en_EN
dc.contributor.funder Ministerio de Economía, Industria y Competitividad
dc.contributor.funder Generalitat Valenciana
dc.contributor.funder Generalitat de Catalunya
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