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dc.contributor.author | POVEDA-REYES, SARA | es_ES |
dc.contributor.author | Rodrigo Navarro, Aleixandre | es_ES |
dc.contributor.author | Gamboa Martínez, Tatiana Carolina | es_ES |
dc.contributor.author | Rodríguez-Cabello, José Carlos | es_ES |
dc.contributor.author | Quintanilla-Sierra, Luis | es_ES |
dc.contributor.author | Edlund, Ulrica | es_ES |
dc.contributor.author | Gallego Ferrer, Gloria | es_ES |
dc.date.accessioned | 2017-09-29T07:35:30Z | |
dc.date.available | 2017-09-29T07:35:30Z | |
dc.date.issued | 2015-09-15 | |
dc.identifier.issn | 0032-3861 | |
dc.identifier.uri | http://hdl.handle.net/10251/88229 | |
dc.description.abstract | [EN] Poly(L-lactic acid) (PLLA) microfibers were surface functionalized by graft photopolymerization of 2-hydroxyethyl methacrylate (HEMA) onto the fiber surface. Grafted fibers were easily dispersed in enzymatically gelling tyramine-substituted gelatin, forming a homogeneous dispersion without hindering subsequent gelatin crosslinking. The obtained injectable hydrogels showed improved mechanical properties compared to analogues based on non-modified fibers. The composite with 1% (w/v) of surface modified fibers had a three-fold higher shear storage modulus (535.2 +/- 90 Pa) than pure gelatin (184.9 +/- 32 Pa) while no significant increase was observed in the case of non-grafted fiber composites. Moreover, PHEMA grafting on PLLA fibers did not compromise cell viability and proliferation within the hydrogel. The new injectable hydrogels offer improved potential as substrates for the regeneration of soft tissues. | es_ES |
dc.description.sponsorship | The authors are grateful for the financial support received from the Spanish Ministry through the MAT2013-46467-C4-1-R project (including the FEDER financial support), the BES-2011-046144 and the EEBB-I-13-06179 grants. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program. CIBER actions are financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. | en_EN |
dc.language | Inglés | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.ispartof | Polymer | es_ES |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Loose microfibers | es_ES |
dc.subject | Surface-grafting | es_ES |
dc.subject | Poly(L-lactic acid) | es_ES |
dc.subject | Enzymatic crosslinking | es_ES |
dc.subject | Injectable hydrogel | es_ES |
dc.subject | Microfiber-hydrogel composite | es_ES |
dc.subject.classification | MAQUINAS Y MOTORES TERMICOS | es_ES |
dc.subject.classification | TERMODINAMICA APLICADA (UPV) | es_ES |
dc.title | Injectable composites of loose microfibers and gelatin with improved interfacial interaction for soft tissue engineering | es_ES |
dc.type | Artículo | es_ES |
dc.identifier.doi | 10.1016/j.polymer.2015.08.018 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//MAT2013-46467-C4-1-R/ES/ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA/ / | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MICINN//BES-2011-046144/ES/BES-2011-046144/ | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//EEBB-I-13-06179/ES/EEBB-I-13-06179/ | es_ES |
dc.rights.accessRights | Cerrado | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
dc.contributor.affiliation | Universitat Politècnica de València. Centro de Biomateriales e Ingeniería Tisular - Centre de Biomaterials i Enginyeria Tissular | es_ES |
dc.description.bibliographicCitation | Poveda-Reyes, S.; Rodrigo Navarro, A.; Gamboa Martinez, TC.; Rodríguez-Cabello, JC.; Quintanilla-Sierra, L.; Edlund, U.; Gallego Ferrer, G. (2015). Injectable composites of loose microfibers and gelatin with improved interfacial interaction for soft tissue engineering. Polymer. 74:224-234. doi:10.1016/j.polymer.2015.08.018 | es_ES |
dc.description.accrualMethod | S | es_ES |
dc.relation.publisherversion | http://dx.doi. org/10.1016/j.polymer.2015.08.018 | es_ES |
dc.description.upvformatpinicio | 224 | es_ES |
dc.description.upvformatpfin | 234 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 74 | es_ES |
dc.relation.senia | 293311 | es_ES |
dc.identifier.eissn | 1873-2291 | |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |