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Dominant frequency and organization index maps in a realistic three-dimensional computational model of atrial fibrillation

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Dominant frequency and organization index maps in a realistic three-dimensional computational model of atrial fibrillation

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dc.contributor.author Tobón Zuluaga, Catalina es_ES
dc.contributor.author Rodriguez, Jose Felix es_ES
dc.contributor.author Ferrero De Loma-Osorio, José María es_ES
dc.contributor.author Hornero, Fernando es_ES
dc.contributor.author Saiz Rodríguez, Francisco Javier es_ES
dc.date.accessioned 2017-09-29T07:43:26Z
dc.date.available 2017-09-29T07:43:26Z
dc.date.issued 2012-11
dc.identifier.issn 1099-5129
dc.identifier.uri http://hdl.handle.net/10251/88235
dc.description.abstract Aims To study, using simulation, the spectral characteristics of different patterns of atrial fibrillation (AF) at high spatial resolution. Dominant frequency (DF) and organization index (OI) maps have been used to approximate the location of the focal source of high frequency during AF events. Methods and results A realistic three-dimensional model of the human atria that includes fibre orientation, electrophysiological heterogeneity, and anisotropy was implemented. The cellular model was modified to simulate electrical remodelling. More than 43 000 electrograms were calculated on the surface, and were processed to reconstitute the DF and OI maps. Atrial fibrillation episodes were triggered by a source of transitory and of continuous activity (both with a cycle length of 130 ms) in five different locations. The maps obtained during the AF events triggered by transitory foci did not show areas with high DF or OI values. When continuous foci were applied, the DF maps show ample zones with high values in the atrium where the focus was applied; while OI maps display smaller areas with high values, always within the areas of high DF and, in three of five locations, this high-value area was located at the site of focus application and at the nearby area. In the other two locations, the area presenting the highest OI values is small and located at the site of focus application, which allowed its precise localization. Conclusion Organization index maps provide a better approximation than DF maps for the localization of ectopic sources of high frequency and continuous activity during episodes of simulated AF in remodelled tissue. es_ES
dc.description.sponsorship This work was partially supported by the Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica, Ministerio de Ciencia e Innovacion of Spain (TEC2008-02090); the Plan Avanza (Accion Estrategica de Telecomunicaciones y Sociedad de la Informacion), Ministerio de Industria Turismo y Comercio of Spain (TSI-020100-2010-469); the Programa Prometeo 2012 of the Generalitat Valenciana; and the Programa de Apoyo a la Investigacion y Desarrollo of the Universitat Politecnica de Valencia (PAID-06-11-2002). en_EN
dc.language Inglés es_ES
dc.publisher Oxford University Press (OUP) es_ES
dc.relation Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica, Ministerio de Ciencia e Innovacion of Spain TEC2008-02090 es_ES
dc.relation Plan Avanza (Accion Estrategica de Telecomunicaciones y Sociedad de la Informacion), Ministerio de Industria Turismo y Comercio of Spain TSI-020100-2010-469 es_ES
dc.relation Programa Prometeo 2012 of the Generalitat Valenciana es_ES
dc.relation Programa de Apoyo a la Investigacion y Desarrollo of the Universitat Politecnica de Valencia PAID-06-11-2002 es_ES
dc.relation.ispartof EP-Europace es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject Atrial fibrillation es_ES
dc.subject Atrial remodeling es_ES
dc.subject Dominant frequency maps and organization index maps es_ES
dc.subject.classification TECNOLOGIA ELECTRONICA es_ES
dc.title Dominant frequency and organization index maps in a realistic three-dimensional computational model of atrial fibrillation es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1093/europace/eus268
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica es_ES
dc.description.bibliographicCitation Tobón Zuluaga, C.; Rodriguez, JF.; Ferrero De Loma-Osorio, JM.; Hornero, F.; Saiz Rodríguez, FJ. (2012). Dominant frequency and organization index maps in a realistic three-dimensional computational model of atrial fibrillation. EP-Europace. 14:25-32. doi:10.1093/europace/eus268 es_ES
dc.description.accrualMethod Senia es_ES
dc.relation.publisherversion http://dx.doi. org/10.1093/europace/eus268 es_ES
dc.description.upvformatpinicio 25 es_ES
dc.description.upvformatpfin 32 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 14 es_ES
dc.relation.senia 243133 es_ES


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