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Effect of a lytic bacteriophage on rabbits experimentally infected with pathogenic Escherichia coli

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Effect of a lytic bacteriophage on rabbits experimentally infected with pathogenic Escherichia coli

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dc.contributor.author Zhao, J. es_ES
dc.contributor.author He, L. es_ES
dc.contributor.author Pan, L. es_ES
dc.contributor.author Liu, Y. es_ES
dc.contributor.author Yao, H. es_ES
dc.contributor.author Bao, G. es_ES
dc.date.accessioned 2017-09-29T08:54:48Z
dc.date.available 2017-09-29T08:54:48Z
dc.date.issued 2017-09-28
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/88258
dc.description.abstract [EN] Pathogenic Escherichia coli (E. coli) is severely threatening the rabbit industry in China, and the concern over antibiotic-resistant bacteria has given rise to an urgent need for antibiotic alternatives. In this study, a member (ZRP1) of the Myoviridae family was isolated from rabbit faeces using a strain of rabbit atypical enteropathogenic E. coli (ZR1) as host. The one-step growth curve indicated that the latent period was around 25 to 30 min and the burst size was 144±31 plaque-forming unit/cell. The rate of phage-resistant mutation was 7×10–5±4×10–5. When the bacteriophage input at the multiplicity of infection (MOI) was 0.1, 1 or 10, the growth of host E. coli in broth was inhibited for 5 h. A single intravenous injection of ZRP1 at MOI 0.1, 1 or 10 significantly prolonged the survival time of rabbits which simultaneously received a lethal dose of ZR1. es_ES
dc.description.sponsorship This work was supported by a grant from the National Rabbit Industry Technology System of P. R. China (CARS44-C-2).
dc.language Inglés es_ES
dc.publisher Universitat Politècnica de València
dc.relation.ispartof World Rabbit Science
dc.rights Reserva de todos los derechos es_ES
dc.subject Atypical enteropathogenic Escherichia coli es_ES
dc.subject Bacteriophage es_ES
dc.subject Phage therapy es_ES
dc.subject Rabbit es_ES
dc.title Effect of a lytic bacteriophage on rabbits experimentally infected with pathogenic Escherichia coli es_ES
dc.type Artículo es_ES
dc.date.updated 2017-09-29T06:57:26Z
dc.identifier.doi 10.4995/wrs.2017.6395
dc.relation.projectID info:eu-repo/grantAgreement/Earmarked Fund for Modern Agro-industry Technology Research System//CARS-44-C-2/ es_ES
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Zhao, J.; He, L.; Pan, L.; Liu, Y.; Yao, H.; Bao, G. (2017). Effect of a lytic bacteriophage on rabbits experimentally infected with pathogenic Escherichia coli. World Rabbit Science. 25(3):273-279. https://doi.org/10.4995/wrs.2017.6395 es_ES
dc.description.accrualMethod SWORD es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.2017.6395 es_ES
dc.description.upvformatpinicio 273 es_ES
dc.description.upvformatpfin 279 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 25
dc.description.issue 3
dc.identifier.eissn 1989-8886
dc.contributor.funder Earmarked Fund for Modern Agro-industry Technology Research System, China


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