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dc.contributor.author | Zhao, J. | es_ES |
dc.contributor.author | He, L. | es_ES |
dc.contributor.author | Pan, L. | es_ES |
dc.contributor.author | Liu, Y. | es_ES |
dc.contributor.author | Yao, H. | es_ES |
dc.contributor.author | Bao, G. | es_ES |
dc.date.accessioned | 2017-09-29T08:54:48Z | |
dc.date.available | 2017-09-29T08:54:48Z | |
dc.date.issued | 2017-09-28 | |
dc.identifier.issn | 1257-5011 | |
dc.identifier.uri | http://hdl.handle.net/10251/88258 | |
dc.description.abstract | [EN] Pathogenic Escherichia coli (E. coli) is severely threatening the rabbit industry in China, and the concern over antibiotic-resistant bacteria has given rise to an urgent need for antibiotic alternatives. In this study, a member (ZRP1) of the Myoviridae family was isolated from rabbit faeces using a strain of rabbit atypical enteropathogenic E. coli (ZR1) as host. The one-step growth curve indicated that the latent period was around 25 to 30 min and the burst size was 144±31 plaque-forming unit/cell. The rate of phage-resistant mutation was 7×10–5±4×10–5. When the bacteriophage input at the multiplicity of infection (MOI) was 0.1, 1 or 10, the growth of host E. coli in broth was inhibited for 5 h. A single intravenous injection of ZRP1 at MOI 0.1, 1 or 10 significantly prolonged the survival time of rabbits which simultaneously received a lethal dose of ZR1. | es_ES |
dc.description.sponsorship | This work was supported by a grant from the National Rabbit Industry Technology System of P. R. China (CARS44-C-2). | |
dc.language | Inglés | es_ES |
dc.publisher | Universitat Politècnica de València | |
dc.relation.ispartof | World Rabbit Science | |
dc.rights | Reserva de todos los derechos | es_ES |
dc.subject | Atypical enteropathogenic Escherichia coli | es_ES |
dc.subject | Bacteriophage | es_ES |
dc.subject | Phage therapy | es_ES |
dc.subject | Rabbit | es_ES |
dc.title | Effect of a lytic bacteriophage on rabbits experimentally infected with pathogenic Escherichia coli | es_ES |
dc.type | Artículo | es_ES |
dc.date.updated | 2017-09-29T06:57:26Z | |
dc.identifier.doi | 10.4995/wrs.2017.6395 | |
dc.relation.projectID | info:eu-repo/grantAgreement/Earmarked Fund for Modern Agro-industry Technology Research System//CARS-44-C-2/ | es_ES |
dc.rights.accessRights | Abierto | es_ES |
dc.description.bibliographicCitation | Zhao, J.; He, L.; Pan, L.; Liu, Y.; Yao, H.; Bao, G. (2017). Effect of a lytic bacteriophage on rabbits experimentally infected with pathogenic Escherichia coli. World Rabbit Science. 25(3):273-279. https://doi.org/10.4995/wrs.2017.6395 | es_ES |
dc.description.accrualMethod | SWORD | es_ES |
dc.relation.publisherversion | https://doi.org/10.4995/wrs.2017.6395 | es_ES |
dc.description.upvformatpinicio | 273 | es_ES |
dc.description.upvformatpfin | 279 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.volume | 25 | |
dc.description.issue | 3 | |
dc.identifier.eissn | 1989-8886 | |
dc.contributor.funder | Earmarked Fund for Modern Agro-industry Technology Research System, China |