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Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites

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Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites

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dc.contributor.author Sonseca Olalla, Agueda es_ES
dc.contributor.author Sahuquillo, Oscar es_ES
dc.contributor.author Foster, E. Johan es_ES
dc.contributor.author Giménez Torres, Enrique es_ES
dc.date.accessioned 2017-12-21T13:58:41Z
dc.date.available 2017-12-21T13:58:41Z
dc.date.issued 2015 es_ES
dc.identifier.issn 2046-2069 es_ES
dc.identifier.uri http://hdl.handle.net/10251/93303
dc.description.abstract [EN] Polyesters based on polyols and sebacic acid, known as poly(polyol sebacate) s (PPS) are good candidates to develop degradable materials, due to their combination of flexibility and degradability, which are both useful properties in the context of soft-tissue engineering (Z. Sun, C. Chen, M. Sun, C. Ai, X. Lu, Y. Zheng, B. Yang and D. Dong, Biomaterials, 2009, 30, 5209, C. Sundback, J. Shyu, Y. Wang, W. Faquin, R. Langer, J. Vacanti and T. Hadlock, Biomaterials, 2005, 26, 5454, D. Motlagh, J. Yang, K. Lui, A. Webb and G. Ameer, Biomaterials, 2006, 27, 4315, A. Mahdavi, L. Ferreira, C. Sundback, J. W. Nichol, E. P. Chan, D. J. D. Carter, C. J. Bettinger, S. Patanavanich, L. Chignozha, E. Ben-Joseph, A. Galakatos, H. Pryor, I. Pomerantseva, P. T. Masiakos, W. Faquin, A. Zumbuehl, S. Hong, J. Borenstein, J. Vacanti, R. Langer and J. M. Karp, Proc. Natl. Acad. Sci. U. S. A., 2008, 105, 2307). However, PPS generally display poor mechanical properties, in particular a low modulus, that limit the true potential of these materials in the biomedical field. Here, we introduce an approach to obtain nanocomposites based on poly(mannitol sebacate) (PMS) matrices reinforced with cellulose nanocrystals (CNCs) in order to improve the application range of these materials. Different strategies were used based on varying the feed ratios between mannitol : sebacic acid (1 : 1 and 1 : 2), crosslinking conditions and CNCs content, resulting in different degrees of crosslinking and, therefore, mechanical and degradation behavior. All of the developed nanocomposites displayed the expected mass loss during the degradation studies in simulated body fluid (SBF) similar to the neat matrix, however, doubling the sebacic acid feed ratio or extending the curing temperature and time, resulted in higher mechanical properties, structural integrity, and shape stability during a degradation time lessening mass loss rate. Changing mannitol : sebacic acid reaction ratios from 1 : 1 to 1 : 2 and for low crosslinking degree neat samples, the Young's modulus increases four-fold, while mass loss after 150 days of incubation is reduced by half. The Young's modulus range obtained with this process covers the range of human elastic soft tissues to tough tissues (0.7-200 MPa). es_ES
dc.description.sponsorship The authors gratefully acknowledge financial support received from Spanish Ministry of Economy and Competitiveness (Project MAT2010/21494-C03), as well as the support of FPU grant from MED (MED-FPU; AP2009-2482) and the Adolphe Merkle Foundation. es_ES
dc.language Inglés es_ES
dc.publisher The Royal Society of Chemistry es_ES
dc.relation.ispartof RSC Advances es_ES
dc.rights Reconocimiento - No comercial (by-nc) es_ES
dc.subject.classification CIENCIA DE LOS MATERIALES E INGENIERIA METALURGICA es_ES
dc.title Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1039/c5ra06768e es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MECD//AP2009-2482/ES/AP2009-2482/ es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MICINN//MAT2010-21494-C03-01/ES/DESARROLLO DE ESPUMAS Y SISTEMAS RIGIDOS CON MEMORIA DE FORMA BASADOS EN NANOCOMPUESTOS BIODEGRADABLES NANONOESTRUCTURADOS/ es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ingeniería Mecánica y de Materiales - Departament d'Enginyeria Mecànica i de Materials es_ES
dc.description.bibliographicCitation Sonseca Olalla, A.; Sahuquillo, O.; Foster, EJ.; Giménez Torres, E. (2015). Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites. RSC Advances. 5(69):55879-55891. https://doi.org/10.1039/c5ra06768e es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1039/c5ra06768e es_ES
dc.description.upvformatpinicio 55879 es_ES
dc.description.upvformatpfin 55891 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 5 es_ES
dc.description.issue 69 es_ES
dc.relation.pasarela S\292961 es_ES
dc.contributor.funder Ministerio de Ciencia e Innovación es_ES
dc.contributor.funder Ministerio de Educación, Cultura y Deporte es_ES


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