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Ginger attenuated di (n-butyl) phthalate-induced reproductive toxicity in pubertal male rabbits

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Ginger attenuated di (n-butyl) phthalate-induced reproductive toxicity in pubertal male rabbits

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dc.contributor.author Oda, S. S. es_ES
dc.contributor.author Waheeb, R. S. es_ES
dc.date.accessioned 2018-01-04T13:53:59Z
dc.date.available 2018-01-04T13:53:59Z
dc.date.issued 2017-12-28
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/93940
dc.description.abstract [EN] This study was conducted to investigate the toxic effects of di (n-butyl) phthalate (DBP) on reproductive functions in male rabbits and the probable protective role of ginger. Twenty rabbits were divided equally into 4 groups: control group; DBP group (520 mg/kg body weight [BW] DBP orally), DBP+ginger group (520 mg/kg BW DBP and 400 mg/kg BW ginger) and ginger group (400 mg/kg BW ginger orally). Treatments were given three-times/week. After 7 wk of the experiment, DBP induced significant reduction in testis and prostate weights, serum and intratesticular testosterone concentrations, sperm counts both mass and progressive sperm motility and live sperms percentage as well as significant elevation of testicular malondialdehyde compared to control group. No significant changes were detected in epididymal weights, serum FSH and serum LH concentrations and testicular total superoxide dismutase and glutathione peroxidase activities in all treated groups. DBP induced considerable histopathological alterations in testis and to minimal extent in epididymis and prostates. Ginger treatment attenuated the significant changes to a certain extent induced by DBP intoxication in male rabbits probably due to its potential to scavenge free radicals. es_ES
dc.description.sponsorship Grateful thanks to Professor Dr. Mahmoud M.A. Elmaghraby for statistical analysis. es_ES
dc.language Inglés es_ES
dc.publisher Universitat Politècnica de València
dc.relation.ispartof World Rabbit Science
dc.rights Reserva de todos los derechos es_ES
dc.subject Di (n-butyl) phthalate es_ES
dc.subject Ginger es_ES
dc.subject Rabbits es_ES
dc.subject Testes es_ES
dc.subject Prostate es_ES
dc.subject Semen quality es_ES
dc.title Ginger attenuated di (n-butyl) phthalate-induced reproductive toxicity in pubertal male rabbits es_ES
dc.type Artículo es_ES
dc.date.updated 2018-01-04T11:44:52Z
dc.identifier.doi 10.4995/wrs.2017.7466
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Oda, SS.; Waheeb, RS. (2017). Ginger attenuated di (n-butyl) phthalate-induced reproductive toxicity in pubertal male rabbits. World Rabbit Science. 25(4):387-398. https://doi.org/10.4995/wrs.2017.7466 es_ES
dc.description.accrualMethod SWORD es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.2017.7466 es_ES
dc.description.upvformatpinicio 387 es_ES
dc.description.upvformatpfin 398 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 25
dc.description.issue 4
dc.identifier.eissn 1989-8886


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