- -

Experimentally induced epizootic rabbit enteropathy: clinical, histopathologicaI, ultrastructural, bacteriological and haematological findings

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

Experimentally induced epizootic rabbit enteropathy: clinical, histopathologicaI, ultrastructural, bacteriological and haematological findings

Show simple item record

Files in this item

dc.contributor.author Dewrée, R.
dc.contributor.author Meulemans, L.
dc.contributor.author Lassence, C.
dc.contributor.author Desmecht, D.
dc.contributor.author Ducatelle, R.
dc.contributor.author Mast, J.
dc.contributor.author Licois, D.
dc.contributor.author Vindevogel, H.
dc.contributor.author Marlier, D.
dc.date.accessioned 2011-02-08T10:50:47Z
dc.date.available 2011-02-08T10:50:47Z
dc.date.issued 2007
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/9479
dc.description.abstract [EN] Epizootic rabbit enteropathy is an emerging disease that has appeared in French intensive enclosed rabbit farms since the beginning of 1997. Common clinical signs are mild watery diarrhoea with considerable distension of the abdomen. At necropsy, a significant dilation of the stomach and small intestine without gross evidence of acute or chronic enteric lesions (inflammation or congestion) was observed. The purpose of this study was to describe the anatomopathologic changes concerning the small intestine and those concerning the blood profile, in experimentally infected rabbits. In a first part of the experiment, thirty animals were inoculated with a reference inoculum and five were kept as controls for clinical signs examination and histopathological study. In a second part, 17 out of the inoculated rabbits and the 5 controls animals were randomly assigned to blood testing. Microscopic lesions were studied in sections from the different parts of the small intestine (duodenum, jejunum and ileum) by light microscopy, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The histological findings revealed only limited inflammation in inoculated animals. Major villous changes were atrophy, fusion, destruction and loss of epithelial cells. In inoculated rabbits, the congestion and dilation of blood vessels of jejunal lamina propria were significantly higher than in control animals (P<0.005). There was significantly more (P<0.05) apoptosis of cells of the jejunal epithelium in inoculated rabbits than in control animals. Infiltration of polymorphonuclear neutrophiles was observed into the jejunal or ileal tunica muscularis. SEM performed on the intestinal tract of 15 inoculated rabbits revealed blankets and globular particles of mucus associated with numerous bacteria on jejunum and ileum villi. This was not observed in the intestinal tract of control rabbits. Bacteria were found adhering to the epithelial surface and inside intestinal epithelial cells in a few animals by TEM and by light microscopy after Warthin-Starry staining. None of the bacteria isolated from the intestinal mixed contents and cultivated on usual media, are commonly known as rabbit's pathogens. Regarding the haematological profile, neutrophil counts significantly increased (P<0.05) and lymphocyte counts significantly decreased (P<0.01), in inoculated rabbits compared to those of the control group. es_ES
dc.language Inglés es_ES
dc.publisher World Rabbit Science. ICTA. UPV es_ES
dc.relation.ispartof World Rabbit Science
dc.rights Reconocimiento - No comercial (by-nc) es_ES
dc.subject Epizootic rabbit enteropathy es_ES
dc.subject Oryctolagus cuniculus es_ES
dc.subject Electron microscopy es_ES
dc.title Experimentally induced epizootic rabbit enteropathy: clinical, histopathologicaI, ultrastructural, bacteriological and haematological findings es_ES
dc.type Artículo es_ES
dc.date.updated 2011-02-08T10:10:49Z
dc.identifier.doi 10.4995/wrs.2007.602
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Dewrée, R.; Meulemans, L.; Lassence, C.; Desmecht, D.; Ducatelle, R.; Mast, J.; Licois, D.... (2007). Experimentally induced epizootic rabbit enteropathy: clinical, histopathologicaI, ultrastructural, bacteriological and haematological findings. World Rabbit Science. 15(2). doi:10.4995/wrs.2007.602 es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.2007.602
dc.description.volume 15
dc.description.issue 2
dc.identifier.eissn 1989-8886 es_ES


This item appears in the following Collection(s)

Show simple item record