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The protective efficacy of vitamins (C and E), selenium and silymarin supplements against alcohol toxicity

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The protective efficacy of vitamins (C and E), selenium and silymarin supplements against alcohol toxicity

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dc.contributor.author Shalan, M.G
dc.contributor.author Abd Ali, W. Dh
dc.contributor.author Shalan, A.G.
dc.date.accessioned 2011-02-08T11:05:24Z
dc.date.available 2011-02-08T11:05:24Z
dc.date.issued 2007
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/9481
dc.description.abstract [EN] This study aimed at investigating the efficacy of vitamins (C and E), selenium and silymarin (an antioxidant complex from Silybum marianum) supplementation in reducing toxic effects of ethanol on liver weight and some blood parameters. Sixty male rabbits, individually housed in steel cages, were randomly divided into three groups. The first was a control group, the second received balanced diet and daily 20% (v/ v) ethyl alcohol in their drinking water, the third received the same diet and 20% (v/v) ethanol in their drinking water and treated with vitamin C (1 mg/100 g body weight, BW), vitamin E (1 mg/100 g BW), selenium (0.01 mg/ 100 g BW) and silymarin (1 mg/100 g body weight) by gastric tube daily. Five animals per group were slaughtered every two weeks and liver and blood samples were taken after 2, 4, 6 and 8 weeks of treatment. Ethanol decreased body weight of rabbits and induced hepatomegally and apoptotic DNA fragmentation in hepatocytes. Chronic alcohol consumption induced significant increases in serum glucose, triglycerides and cholesterol levels whereas serum total protein content decreased. Significant increases in serum ALT, AST, ALP and LDH activities were observed in ethanol-treated rabbits. The treatment of alcohol-abused animals with vitamins (C and E), selenium and silymarin enhanced significant improvement in the biochemical, physiological and molecular aspects indicating their protective effects against alcohol toxicity. es_ES
dc.language Inglés es_ES
dc.publisher World Rabbit Science. ICTA. UPV es_ES
dc.relation.ispartof World Rabbit Science
dc.rights Reconocimiento - No comercial (by-nc) es_ES
dc.subject Rabbits es_ES
dc.subject Alcohol toxicity es_ES
dc.subject Vitamin c es_ES
dc.subject Vitamin e es_ES
dc.subject Selenium es_ES
dc.subject Silymarin es_ES
dc.title The protective efficacy of vitamins (C and E), selenium and silymarin supplements against alcohol toxicity es_ES
dc.type Artículo es_ES
dc.date.updated 2011-02-08T10:10:57Z
dc.identifier.doi 10.4995/wrs.2007.601
dc.rights.accessRights Abierto es_ES
dc.description.bibliographicCitation Shalan, M.; Abd Ali, WD.; Shalan, A. (2007). The protective efficacy of vitamins (C and E), selenium and silymarin supplements against alcohol toxicity. World Rabbit Science. 15(2). doi:10.4995/wrs.2007.601 es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.2007.601
dc.description.volume 15
dc.description.issue 2
dc.identifier.eissn 1989-8886 es_ES


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