- -

2,4-dinitrophenyl ether-containing chemodosimeters for the selective and sensitive 'in vitro' and 'in vivo' detection of hydrogen sulfide

RiuNet: Institutional repository of the Polithecnic University of Valencia

Share/Send to

Cited by

Statistics

2,4-dinitrophenyl ether-containing chemodosimeters for the selective and sensitive 'in vitro' and 'in vivo' detection of hydrogen sulfide

Show simple item record

Files in this item

dc.contributor.author El Sayed Shehata Nasr, Sameh es_ES
dc.contributor.author De La Torre, C, es_ES
dc.contributor.author Santos Figueroa, Luis E. es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Orzáez, M. es_ES
dc.contributor.author Costero, Ana M. es_ES
dc.contributor.author Parra, Margarita es_ES
dc.contributor.author Gil, Salvador es_ES
dc.date.accessioned 2018-01-30T12:18:26Z
dc.date.available 2018-01-30T12:18:26Z
dc.date.issued 2015 es_ES
dc.identifier.issn 1061-0278 es_ES
dc.identifier.uri http://hdl.handle.net/10251/96085
dc.description.abstract [EN] Four probes (i.e. D1¿D4) for the selective and sensitive fluorogenic detection of HS2 have been prepared and characterised. HEPES (10 mM, pH 7.4)¿DMSO 99:1 v/v solutions of D1¿D4 are essentially non-fluorescent. Changes in the emission using D1¿D4 in the presence of anions (F2, Cl2, Br2, I2, N2 3 , CN2, SCN2, AcO2, CO22 3 , PO22 4 , SO22 4 , HS2 and OH2), biothiols (GSH, Cys, Hcy, Me ¿Cys and lipoic acid), reducing agents (SO22 3 and S2O22 3 ) and oxidants (H2O2) demonstrated that only HS2 is able to induce the appearance of intense emission bands in the 400¿ 520 nm range in the four probes. The selectivity observed was ascribed to a unique hydrogen sulfide-induced hydrolysis of the 2,4-dinitrophenyl ether moiety that yielded the corresponding free highly fluorescent alcohols. The potential detection of intracellular HS2 was also studied. es_ES
dc.description.sponsorship Financial support from the Spanish Government (Project MAT2012-38429-C04-01) and the Generalitat Valencia (Project PROMETEO/2009/016) is gratefully acknowledged. S.E. is grateful to the Generalitat Valenciana for his Santiago Grisolia fellow. L.E.S.F. also thanks the Carolina Foundation and UPNFM-Honduras for his doctoral grant. es_ES
dc.language Inglés es_ES
dc.publisher Taylor & Francis es_ES
dc.relation MINECO/MAT2012-38429-C04-01 es_ES
dc.relation GVA/PROMETEO/2009/016 es_ES
dc.relation.ispartof Supramolecular Chemistry es_ES
dc.rights Reserva de todos los derechos es_ES
dc.subject In vivo detection es_ES
dc.subject Fluorescence es_ES
dc.subject Dinitrophenyl ether es_ES
dc.subject Chemodosimeter es_ES
dc.subject Hydrogen sulfide es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.title 2,4-dinitrophenyl ether-containing chemodosimeters for the selective and sensitive 'in vitro' and 'in vivo' detection of hydrogen sulfide es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1080/10610278.2014.977286 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation El Sayed Shehata Nasr, S.; De La Torre, C.; Santos Figueroa, LE.; Martínez-Máñez, R.; Sancenón Galarza, F.; Orzáez, M.; Costero Nieto, AM.... (2015). 2,4-dinitrophenyl ether-containing chemodosimeters for the selective and sensitive 'in vitro' and 'in vivo' detection of hydrogen sulfide. Supramolecular Chemistry. 27(4):244-254. doi:10.1080/10610278.2014.977286 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion http://doi.org/10.1080/10610278.2014.977286 es_ES
dc.description.upvformatpinicio 244 es_ES
dc.description.upvformatpfin 254 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 27 es_ES
dc.description.issue 4 es_ES
dc.relation.pasarela 313256 es_ES
dc.contributor.funder GENERALITAT VALENCIANA es_ES
dc.contributor.funder MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD es_ES


This item appears in the following Collection(s)

Show simple item record