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Technical Note: Time and dose response of blood non-esterified fatty acids to adrenergic stimulation in rabbit does

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Technical Note: Time and dose response of blood non-esterified fatty acids to adrenergic stimulation in rabbit does

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dc.contributor.author Theilgaard, P.
dc.contributor.author Facila, S.
dc.contributor.author Blas, E.
dc.contributor.author Baselga, M.
dc.contributor.author Pascual Amorós, Juan José
dc.date.accessioned 2011-02-11T13:03:57Z
dc.date.available 2011-02-11T13:03:57Z
dc.date.issued 2005
dc.identifier.issn 1257-5011
dc.identifier.uri http://hdl.handle.net/10251/9713
dc.description.abstract [EN] The response in blood non-esterified fatty acids (NEFA) to an adrenergic stimulation was studied in rabbit does. Two separate experiments were carried out to find the best time interval for blood sampling after an adrenergic stimulation and to find the appropriate dose for the challenging stimulus. In the first experiment, the time evolution was studied by injecting 9 animals intravenously with 50 mg of isoproterenol per kg of live weight (LW), blood being collected just before and 5, 10, 15, 20, 30 and 40 minutes after challenge. The highest NEFA responses, calculated as the difference between NEFA concentration in samples taken before and after adrenergic stimulation, were observed at 5 and 10 minutes after challenge (+0.70±0.15 and +0.77±0.15 mmol/L, respectively). In the second experiment, 6 animals were consecutively injected with isoproterenol (0.5, 5 or 50 mg/kg LW) and placebo (NaCl, 0.9%) with an interval of 1 hour; and blood was sampled just before and 7.5 minutes after challenge. The NEFA responses were significantly different from zero only when isoproterenol was injected at the dose of 50 mg/kg LW. Thus, we concluded that, among the tested dose concentrations of isoproterenol, 50 mg/kg LW was the most useful dose for adrenergic stimulation and that the adrenergic response was highest at 5 and 10 minutes after challenge. es_ES
dc.description.sponsorship This work was supported by the Spanish Research Project AGL 2004-02710 (CICYT)
dc.language Inglés es_ES
dc.publisher World Rabbit Science. ICTA. UPV es_ES
dc.relation.ispartof World Rabbit Science
dc.rights Reserva de todos los derechos es_ES
dc.subject Rabbit es_ES
dc.subject Adrenergic stimulation es_ES
dc.subject Non-esterified fatty acids es_ES
dc.subject Dose response es_ES
dc.subject Time response es_ES
dc.title Technical Note: Time and dose response of blood non-esterified fatty acids to adrenergic stimulation in rabbit does es_ES
dc.type Artículo es_ES
dc.date.updated 2011-02-11T12:39:26Z
dc.identifier.doi 10.4995/wrs.2005.518 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/MEC//AGL2004-02710/ES/MEJORA GENETICA DEL CONEJO DE CARNE: REPRODUCCION Y LONGEVIDAD/
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Ciencia y Tecnología Animal - Institut de Ciència i Tecnologia Animal es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Ciencia Animal - Departament de Ciència Animal es_ES
dc.contributor.affiliation Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural es_ES
dc.description.bibliographicCitation Theilgaard, P.; Facila, S.; Blas, E.; Baselga, M.; Pascual Amorós, JJ. (2005). Technical Note: Time and dose response of blood non-esterified fatty acids to adrenergic stimulation in rabbit does. World Rabbit Science. 13(3). https://doi.org/10.4995/wrs.2005.518 es_ES
dc.description.accrualMethod SWORD es_ES
dc.relation.publisherversion https://doi.org/10.4995/wrs.2005.518 es_ES
dc.description.volume 13
dc.description.issue 3
dc.identifier.eissn 1989-8886 es_ES
dc.contributor.funder Ministerio de Educación y Ciencia


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