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Two New Fluorogenic Aptasensors Based on Capped Mesoporous Silica Nanoparticles to Detect Ochratoxin A

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Two New Fluorogenic Aptasensors Based on Capped Mesoporous Silica Nanoparticles to Detect Ochratoxin A

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dc.contributor.author Ribes, Àngela es_ES
dc.contributor.author Santiago Felipe, Sara es_ES
dc.contributor.author Bernardos Bau, Andrea es_ES
dc.contributor.author Marcos Martínez, María Dolores es_ES
dc.contributor.author Pardo Vicente, María Teresa es_ES
dc.contributor.author Sancenón Galarza, Félix es_ES
dc.contributor.author Martínez-Máñez, Ramón es_ES
dc.contributor.author Aznar, Elena es_ES
dc.date.accessioned 2018-03-15T05:20:36Z
dc.date.available 2018-03-15T05:20:36Z
dc.date.issued 2017 es_ES
dc.identifier.issn 2191-1363 es_ES
dc.identifier.uri http://hdl.handle.net/10251/99372
dc.description.abstract [EN] Aptamers have been used as recognition elements for several molecules due to their great affinity and selectivity. Additionally, mesoporous nanomaterials have demonstrated great potential in sensing applications. Based on these concepts, we report herein the use of two aptamer¿capped mesoporous silica materials for the selective detection of ochratoxin¿A (OTA). A specific aptamer for OTA was used to block the pores of rhodamine¿B¿loaded mesoporous silica nanoparticles. Two solids were prepared in which the aptamer capped the porous scaffolds by using a covalent or electrostatic approach. Whereas the prepared materials remained capped in water, dye delivery was selectively observed in the presence of OTA. The protocol showed excellent analytical performance in terms of sensitivity (limit of detection: 0.5¿0.05¿nm), reproducibility, and selectivity. Moreover, the aptasensors were tested for OTA detection in commercial foodstuff matrices, which demonstrated their potential applicability in real samples es_ES
dc.description.sponsorship We thank the Spanish Government (projects MAT2015-64139-C4-1-R and AGL2015-70235-C2-2-R (MINECO/FEDER)) and the Generalitat Valenciana (project PROMETEOII/2014/047) for support. A.R. thanks UPV for her predoctoral fellowship. S.S. thanks the Instituto de Salud Carlos III and the European Social Fund for the financial support "Sara Borrell" (CD16/000237). A.B. thanks the Spanish Government for financial support by the "Juan de la Cierva-Incorporacion" (IJCI-2014-21534). The authors also thank the Electron Microscopy Service at UPV for support. en_EN
dc.language Inglés es_ES
dc.publisher John Wiley & Sons es_ES
dc.relation GENERALITAT VALENCIANA/PROMETEOII/2014/047 es_ES
dc.relation MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD /MAT2015-64139-C4-1-R es_ES
dc.relation MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD /AGL2015-70235-C2-2-R es_ES
dc.relation.ispartof ChemistryOpen es_ES
dc.rights Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) es_ES
dc.subject Aptamers es_ES
dc.subject Mesoporous materials es_ES
dc.subject Nanostructures es_ES
dc.subject Ochratoxin A es_ES
dc.subject Sensors es_ES
dc.subject Electron Microscopy Service of the UPV
dc.subject.classification INGENIERIA DE LA CONSTRUCCION es_ES
dc.subject.classification QUIMICA INORGANICA es_ES
dc.subject.classification QUIMICA ORGANICA es_ES
dc.subject.classification QUIMICA ANALITICA es_ES
dc.title Two New Fluorogenic Aptasensors Based on Capped Mesoporous Silica Nanoparticles to Detect Ochratoxin A es_ES
dc.type Artículo es_ES
dc.identifier.doi 10.1002/open.201700106 es_ES
dc.rights.accessRights Abierto es_ES
dc.contributor.affiliation Universitat Politècnica de València. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico - Institut de Reconeixement Molecular i Desenvolupament Tecnològic es_ES
dc.contributor.affiliation Universitat Politècnica de València. Departamento de Química - Departament de Química es_ES
dc.description.bibliographicCitation Ribes, À.; Santiago Felipe, S.; Bernardos Bau, A.; Marcos Martínez, MD.; Pardo Vicente, MT.; Sancenón Galarza, F.; Martínez-Máñez, R.... (2017). Two New Fluorogenic Aptasensors Based on Capped Mesoporous Silica Nanoparticles to Detect Ochratoxin A. ChemistryOpen. 6(5):653-659. doi:10.1002/open.201700106 es_ES
dc.description.accrualMethod S es_ES
dc.relation.publisherversion https://doi.org/10.1002/open.201700106 es_ES
dc.description.upvformatpinicio 653 es_ES
dc.description.upvformatpfin 659 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.description.volume 6 es_ES
dc.description.issue 5 es_ES
dc.identifier.pmid 29046860 en_EN
dc.identifier.pmcid PMC5641899 en_EN
dc.relation.pasarela 347022 es_ES
dc.contributor.funder GENERALITAT VALENCIANA es_ES
dc.contributor.funder MINISTERIO DE ECONOMIA INDUSTRIA Y COMPETITIVIDAD es_ES


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