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Browsing by Author "La Peña del Rivero, Marcos de"

Now showing items 1-9 of 9

Análisis de RNAs catalíticos en retroelementos de plantas

Martín Guindal, Andrea (Universitat Politècnica de València, 2018-02-12)

Self-cleaving ribozymes such as the hammerhead (HHR), the hepatitis-¿ (HDV) or the twister (Tw) motifs, are a group of small catalytic RNAs with a numerous and widespread occurrence in the genomes of organisms from all ...
Análisis del autocorte ribozimático y la expresión de los retroelementos tipo Penélope en la especie Selaginella moellendorffii

Seguí Pérez, Alba (Universitat Politècnica de València, 2020-09-10)

[ES] A principio de los años 80 se descubrieron unas moléculas catalíticas cuyo centro activo estaba compuesto completamente por RNA y que se denominaron RNAs catalíticos o ribozimas. Desde su descubrimiento hasta ahora ...
Crystal structure of vaccinia virus mRNA capping enzyme provides insights into the mechanism and evolution of the capping apparatus

Kyrieleis, Otto J. P.; Chang, Jonathan; La Peña Del Rivero, Marcos De; Shuman, Stewart; Cusack, Stephen (Elsevier, 2014-03-04)

[EN] Vaccinia virus capping enzyme is a heterodimer of D1 (844 aa) and D12 (287 aa) polypeptides that executes all three steps in m(7)GpppRNA synthesis. The D1 subunit comprises an N-terminal RNA triphosphatase ...
Eukaryotic penelope-like retroelements encode hammerhead ribozyme motifs

Cervera Olagüe, Amelia; La Peña del Rivero, Marcos de (Oxford University Press (OUP), 2014-11)

[EN] Small self-cleaving RNAs, such as the paradigmatic Hammerhead ribozyme (HHR), have been recently found widespread in DNA genomes across all kingdoms of life. In this work, we found that new HHR variants are preserved ...
Intronic hammerhead ribozymes in mRNA biogenesis

García Robles, Inmaculada; Sanchez Navarro, Jesus Angel; La Peña del Rivero, Marcos de (Walter de Gruyter, 2012)

[EN] Small self-cleaving ribozymes are a group of natural RNAs that are capable of catalyzing their own and sequence-specific endonucleolytic cleavage. One of the most studied members is the hammerhead ribozyme (HHR), a ...
Retrozymes are a unique family of non-autonomous retrotransposons with hammerhead ribozymes that propagate in plants through circular RNAs

Cervera, Amelia; Urbina, Denisse; La Peña del Rivero, Marcos de (BioMed Central, 2016-06-23)

[EN] Background: Catalytic RNAs, or ribozymes, are regarded as fossils of a prebiotic RNA world that have remained in the genomes of modern organisms. The simplest ribozymes are the small self-cleaving RNAs, like the ...
Ribozimas en RNAs circulares como herramienta biotecnológica para el silenciamiento génico y viral: una nueva aproximación contra el SARS-CoV2

Muñoz Triviño, Jorge Jaime (Universitat Politècnica de València, 2021-07-30)

[ES] En el contexto de una pandemia mundial, ocasionada por el virus SARS-CoV2, que ha provocado más de cuatro millones de fallecidos en apenas más de un año, el surgimiento de nuevas estrategias terapéuticas para luchar ...
Ribozimas tipo Hairpin en el genoma de arroz revelan una antigua integración de un satélite viral de RNA

Contreras Garrido, Adrián Antonio (Universitat Politècnica de València, 2017-02-21)

[EN] Catalytic RNAs or ribozymes are considered survivors o f an hypothetic pre - biotic RNA world that would ha ve remained conserved in today organisms’ genomes. Most of the known catalytic RNA are short ...
Simultaneous boron ion-channel/growth factor receptor activation for enhanced vascularization

Rico Tortosa, Patricia María; Rodrigo Navarro, Aleixandre; La Peña Del Rivero, Marcos De; Moulisova, Vladimira; Costell, Mercedes; Salmerón Sánchez, Manuel (John Wiley & Sons, 2018-10-30)

[EN] Boron ion is essential in metabolism and its concentration is regulated by ion-channel NaBC1. NaBC1 mutations cause corneal dystrophies such as Harboyan syndrome. Here we propose a 3D molecular model for NaBC1 and ...