Martín Guindal, Andrea(Universitat Politècnica de València, 2018-02-12)
Self-cleaving ribozymes such as the hammerhead (HHR), the hepatitis-¿ (HDV) or the twister (Tw) motifs, are a group of small catalytic RNAs with a numerous and widespread occurrence in the genomes of organisms from all ...
Seguí Pérez, Alba(Universitat Politècnica de València, 2020-09-10)
[ES] A principio de los años 80 se descubrieron unas moléculas catalíticas cuyo centro activo estaba compuesto completamente por RNA y que se denominaron RNAs catalíticos o ribozimas. Desde su descubrimiento hasta ahora ...
Kyrieleis, Otto J. P.; Chang, Jonathan; La Peña Del Rivero, Marcos De; Shuman, Stewart; Cusack, Stephen(Elsevier, 2014-03-04)
[EN] Vaccinia virus capping enzyme is a heterodimer of D1 (844 aa) and D12 (287 aa) polypeptides that executes all three steps in m(7)GpppRNA synthesis. The D1 subunit comprises an N-terminal RNA triphosphatase ...
Cervera Olagüe, Amelia; La Peña del Rivero, Marcos de(Oxford University Press (OUP), 2014-11)
[EN] Small self-cleaving RNAs, such as the paradigmatic Hammerhead ribozyme (HHR), have been recently found widespread in DNA genomes across all kingdoms of life. In this work, we found that new HHR variants are preserved ...
García Robles, Inmaculada; Sanchez Navarro, Jesus Angel; La Peña del Rivero, Marcos de(Walter de Gruyter, 2012)
[EN] Small self-cleaving ribozymes are a group of natural RNAs that are capable of catalyzing their own and sequence-specific endonucleolytic cleavage. One of the most studied members is the hammerhead ribozyme (HHR), a ...
Cervera, Amelia; Urbina, Denisse; La Peña del Rivero, Marcos de(BioMed Central, 2016-06-23)
[EN] Background: Catalytic RNAs, or ribozymes, are regarded as fossils of a prebiotic RNA world that have remained in
the genomes of modern organisms. The simplest ribozymes are the small self-cleaving RNAs, like the ...
Muñoz Triviño, Jorge Jaime(Universitat Politècnica de València, 2021-07-30)
[ES] En el contexto de una pandemia mundial, ocasionada por el virus SARS-CoV2, que ha provocado más de cuatro millones de fallecidos en apenas más de un año, el surgimiento de nuevas estrategias terapéuticas para luchar ...
Contreras Garrido, Adrián Antonio(Universitat Politècnica de València, 2017-02-21)
[EN] Catalytic RNAs or ribozymes are considered survivors o
f an hypothetic pre
-
biotic RNA world that would
ha
ve remained conserved in today
organisms’ genomes. Most of the known catalytic RNA
are short ...
[EN] Boron ion is essential in metabolism and its concentration is regulated by ion-channel NaBC1. NaBC1 mutations cause corneal dystrophies such as Harboyan syndrome. Here we propose a 3D molecular model for NaBC1 and ...