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Browsing by Author "Rodrigo Tarrega, Guillermo"

Now showing items 1-20 of 26

A meta-analysis reveals the commonalities and differences in Arabidopsis thaliana response to different viral pathogens

Rodrigo Tarrega, Guillermo; Carrera Montesinos, Javier; Ruiz-Ferrer, Virginia; Del Toro, F.J.; Llave, C; Voinnet, O.; Elena Fito, Santiago Fco (Public Library of Science, 2012-07)

Understanding the mechanisms by which plants trigger host defenses in response to viruses has been a challenging problem owing to the multiplicity of factors and complexity of interactions involved. The advent of genomic ...
Análisis y diseño de circuitos genéticos sintéticos para aplicaciones energéticas y para la participación del equipo valenciano en la competición "International Genetically Engineered Machine" organizada por el Massachusetts Institute of Technology

Rodrigo Tarrega, Guillermo (Universitat Politècnica de València, 2014-04-08)

Proyecto Confidencial
Automated sequence design of nucleic acid hybridization reactions for microRNA detection

Goiriz Beltrán, Lucas (Universitat Politècnica de València, 2019-09-05)

[EN] microRNA (miRNA) can be found in a variety of biological samples and then they represent important molecular markers for early diagnostic strategies. This work (TFG) explores a novel approach based on nested ...
Boolean Computation in Plants Using Post-translational Genetic Control and a Visual Output Signal

Cordero-Cucart, María Teresa; Rosado, A.; Majer, Eszter; Jaramillo Rosales, Alfonso; Rodrigo Tarrega, Guillermo; Daros Arnau, Jose Antonio (American Chemical Society, 2018-10)

[EN] Due to autotrophic growing capacity and extremely rich secondary metabolism, plants should be preferred targets of synthetic biology. However, developments in plants usually run below those in other taxonomic groups. ...
Computational design and designability of gene regulatory networks

Rodrigo Tarrega, Guillermo (Universitat Politècnica de València, 2011-12-30)

Nuestro conocimiento de las interacciones moleculares nos ha conducido hoy hacia una perspectiva ingenieril, donde diseños e implementaciones de sistemas artificiales de regulación intentan proporcionar instrucciones ...
CRISPR-Cas12a-Based Detection of SARS-CoV-2 Harboring the E484K Mutation

Marqués, María-Carmen; Ruiz, Raúl; Montagud-Martínez, Roser; Márquez-Costa, Rosa; Albert, Sandra; Domingo-Calap, Pilar; Rodrigo Tarrega, Guillermo (American Chemical Society, 2021-12-17)

[EN] The novel respiratory virus SARS-CoV-2 is rapidly evolving across the world with the potential of increasing its transmission and the induced disease. Here, we applied the CRISPR-Cas12a system to detect, without the ...
CRISPR-Mediated Strand Displacement Logic Circuits with Toehold-Free DNA

Montagud-Martínez, Roser; Heras-Hernández, María; Goiriz, Lucas; Rodrigo Tarrega, Guillermo; Daròs, José-Antonio (American Chemical Society, 2021-05-21)

[EN] DNA nanotechnology, and DNA computing in particular, has grown extensively over the past decade to end with a variety of functional stable structures and dynamic circuits. However, the use as designer elements of ...
Describing the structural robustness landscape of bacterial small RNAs

Rodrigo Tarrega, Guillermo; Fares Riaño, Mario Ali (BioMed Central, 2012-04-13)

Background: The potential role of RNA molecules as gene expression regulators has led to a new perspective on the intracellular control and genome organization. Because secondary structures are crucial for their regulatory ...
Dynamic signal processing by ribozyme-mediated RNA circuits to control gene expression

Shen, Shensi; Rodrigo Tarrega, Guillermo; Prakash, Satya; Majer, Eszter; Landrain, T.E.; Kirov, Boris; Daros Arnau, Jose Antonio; Jaramillo, Alfonso (Oxford University Press (OUP), 2015-05-26)

[EN] Organisms have different circuitries that allow converting signal molecule levels to changes in gene expression. An important challenge in synthetic biology involves the de novo design of RNA modules enabling dynamic ...
Estudio del uso del sistema CRISPR-Cas13 para la regulación de la expresión génica in vivo y para aplicaciones de diagnóstico in vitro

Soria Gonzalvo, Ángela (Universitat Politècnica de València, 2022-09-06)

[ES] Los organismos procariotas presentan sistemas inmunológicos que, guiados por RNA, escinden elementos genéticos desconocidos mediante un sistema basado en repeticiones palindrómicas cortas interespaciadas agrupadas ...
Exploring the Dynamics and Mutational Landscape of Riboregulation with a Minimal Synthetic Circuit in Living Cells

Rodrigo Tarrega, Guillermo; Majer, Eszter; Prakash, Satya; Daros Arnau, Jose Antonio; Jaramillo, Alfonso; Poyatos, Juan F. (Biophysical Society, 2015-09-01)

[EN] The regulation of gene expression, triggered by conformational changes in RNA molecules, is widely observed in cellular systems. Here, we examine this mode of control by means of a model-based design and construction ...
Full design automation of multi-state RNA devices to program gene expression using energy-based optimization

Rodrigo Tarrega, Guillermo; Landrain, Thomas E.; Majer, Eszter; Daros Arnau, Jose Antonio; Jaramillo, Alfonso (Public Library of Science, 2013-08)

[EN] Small RNAs (sRNAs) can operate as regulatory agents to control protein expression by interaction with the 59 untranslated region of the mRNA. We have developed a physicochemical framework, relying on base pair ...
Functionalization of an Antisense Small RNA

Rodrigo Tarrega, Guillermo; Prakash, Satya; Cordero-Cucart, María Teresa; Kushwaha, Manish; Jaramillo, Alfonso (Elsevier, 2016-02-27)

[EN] In order to explore the possibility of adding new functions to preexisting genes, we considered a framework of riboregulation. We created a new riboregulator consisting of the reverse complement of a known riboregulator. ...
Genetic redundancies enhance information transfer in noisy regulatory circuits

Rodrigo Tarrega, Guillermo; Poyatos, Juan F. (Public Library of Science, 2016-10)

[EN] Cellular decision making is based on regulatory circuits that associate signal thresholds to specific physiological actions. This transmission of information is subjected to molecular noise what can decrease its ...
Identification, introgression, and validation of fruit volatile QTLs from a red-fruited wild tomato species

Rambla Nebot, Jose Luis; Medina, Aurora; Fernández Del Carmen, María Asunción; Barrantes, Walter; Grandillo, Silvana; Cammareri, Maria; López Casado, Gloria; Rodrigo Tarrega, Guillermo; Alonso, Arancha; Garcia-Martinez, S; Primo Millo, Jaime; Ruiz, JJ; Fernandez-Muñoz, R; Monforte Gilabert, Antonio José; Granell Richart, Antonio (Oxford University Press (OUP), 2016-01)

[EN] Volatile organic compounds (VOCs) are major determinants of fruit flavor, a primary objective in tomato breeding. A recombinant inbred line (RIL) population consisting of 169 lines derived from a cross between Solanum ...
Inferring the Regulatory Network of the miRNA-mediated Response to Biotic and Abiotic Stress in Melon

Sanz-Carbonell, Alejandro; Marques Romero, Mª Carmen; Bustamante-González, Antonio Javier; Fares Riaño, Mario Ali; Rodrigo Tarrega, Guillermo; Gomez, Gustavo Germán (Springer (Biomed Central Ltd.), 2019-02-18)

[EN] Background: MiRNAs have emerged as key regulators of stress response in plants, suggesting their potential as candidates for knock-in/out to improve stress tolerance in agricultural crops. Although diverse assays have ...
Integral control during gravitropism through the interplay of hormonal signaling and gene regulation

Rodrigo Tarrega, Guillermo; Jaramillo, Alfonso; Blazquez Rodriguez, Miguel Angel (Elsevier, 2011)

The interplay between hormone signaling and gene regulatory networks is instrumental in promoting the development of living organisms. In particular, plants have evolved mechanisms to sense gravity and orient themselves ...
Interaction network of tobacco etch potyvirus NIa protein with the host proteome during infection

Martinez Roberto, Fernando; Rodrigo Tarrega, Guillermo; Aragones, Verónica; Ruiz Server, Marta; Lodewijk, Iris; Fernandez, Unai; Elena Fito, Santiago Fco; Daros Arnau, Jose Antonio (BioMed Central, 2016-02-01)

Conclusions: Potyviral NIa targets many host elements during infection, establishing a network in which information is efficiently transmitted.
MicroRNA precursors are not structurally robust but plastic

Rodrigo Tarrega, Guillermo; Elena Fito, Santiago Fco (Oxford University Press (OUP), 2013)

Robustness is considered a ubiquitous property of living systems at all levels of organization, and small noncoding RNA (sncRNA) is a genuine model for its study at the molecular level. In this communication, we question ...
Molecular signatures of silencing suppression degeneracy from a complex RNA virus

Ambrós, Silvia; Gómez-Muñoz, Neus; Giménez-Santamarina, Silvia; Sánchez-Vicente, Javier; Navarro-López, Josep; Martínez, Fernando; Daròs, José-Antonio; Rodrigo Tarrega, Guillermo (Public Library of Science, 2021-06)

[EN] As genomic architectures become more complex, they begin to accumulate degenerate and redundant elements. However, analyses of the molecular mechanisms underlying these genetic architecture features remain scarce, ...